EPO (Erythropoietin)

Additionally, CRISPR-Cas9-mediated knockdown of EPO resulted in the abrogation of cell proliferation, whereas EPOR knockdown showed no effect, suggesting that Epo promotes N2A cell proliferation through an EpoR-independent mechanism. Collectively, these findings highlight the potential of the N2A+Epo cell line as a model for identifying alternative tissue-protective Epo receptors.

Diagnosis of congenital anemias has been complicated by their similar characteristics with DBA, but genetic testing is important in detecting rare causes of these disorders. This diagnosis enabled us to use recombinant human EPO therapy which reduced the need for blood transfusion.

Advances in molecular hematology are expected to improve the characterization of "idiopathic erythrocytosis". Results from prospective studies are needed to elucidate the underlying pathology and guide management.

In esophageal carcinoma, HIF-1α and Epo were strongly expressed at the earliest stages of carcinogenesis. As the carcinoma progressed beyond the muscularis mucosae, the expression of these markers significantly declined, suggesting a resolution of hypoxia likely associated with active angiogenesis.

Mice lacking EPOR from mature oligodendrocytes show subtle deficiencies of adult myelination in hippocampal fimbria and mild working memory deficits. These gain- and loss-of-function experiments may further suggest EPO as clinically safe treatment for remyelination therapies.

The mechanism of action may involve activation of EPO activity, promotion of endogenous antioxidant pathways, and inhibition of neuroinflammation in the white matter. This study suggests that MeBavaC exhibits antioxidant and anti-neuroinflammatory effects, showing potential application in improving cognitive dysfunction.

Additionally, GEMORNA's versatility extends to circular RNA, substantially enhancing circular EPO expression and boosting anti-tumor cytotoxicity in CAR-T cells. These advancements highlight deep generative AI's vast potential for mRNA therapeutics.

Hypoxia increased EPOR mRNA in the Caki-1 cells at 10% FBS, but decreased in the 786-O cells at 2% FBS after 48 h. JAK2/STAT5A activity was increased only in HIF1A-positive tumors. These results suggest that EPO/EPOR activation in ccRCC is mainly driven by low oxygen, not VHL regulation of hypoxia-related responses.

Furthermore, the ability of the rejuvenated cells to produce EPO was maintained in hypoxia. Thus, EPO production is controlled by epigenetic mechanisms and hypoxia signaling in the immature state of hypoxic NEP cells.

P=N/A, N=180, Completed, Ain Shams University | Recruiting --> Completed

The overall data suggest that erythrocyte turnover is severely modulated with the progression of tumor. The apoptosis, ROS levels, antioxidant, anti-apoptotic, and Epo gene expressions were increased, but proapoptotic and anti-inflammatory gene expression were suppressed.