It was stated that the AHR, EPHX1, GSTP1, and SLC25A32 did not correlate in healthy intestinal tissue whereas AHCY, ALDH1A1, NNMT, GSTM4, UGT2B17, and SLCO1B3 did not correlate in CRC. The disturbed transcriptional activity of genes related to the biotransformation process at all stages of CRC suggests that this may be the cause of its occurrence; the genes ought to be taken into account in preventive strategies and the treatment of patients.
2 months ago
Journal
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GSTP1 (Glutathione S-transferase pi 1) • SLCO1B3 (Solute carrier organic anion transporter family member 1B3) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • ADH1C (Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide) • EPHX1 (Epoxide Hydrolase 1) • NNMT (Nicotinamide N-Methyltransferase) • SLC25A3 (Solute Carrier Family 25 Member 3) • UGT2B17 (UDP Glucuronosyltransferase Family 2 Member B17) • SLC29A2 (Solute Carrier Family 29 Member 2) • SLC5A6 (Solute Carrier Family 5 Member 6)
In summary, we conclude that EPHX1 enhances regorafenib resistance in HCC by activating the JAK/STAT signaling pathway. Our findings suggest that EPHX1 is a key resistance-related gene, which has significant implications for the application of regorafenib in advanced HCC.
Temporal comparison with a delayed timepoint (6 weeks post-DOX) uncovered dynamic remodeling of cardiac signaling, with early response dominated by inflammatory and apoptotic responses, and delayed response marked by cell cycle and DNA repair pathway activation. This integrated-omics study reveals key molecular pathways and temporal changes in DOX-induced cardiotoxicity, identifying potential biomarkers for future cardioprotective strategies.
7 months ago
Journal
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CD74 (CD74 Molecule) • EPHX1 (Epoxide Hydrolase 1) • NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1) • SERPINA3 (Serpin Family A Member 3)
Our results reveal an association between EPHX1 rs1051740 and AKD, and confirms the previously reported associations between ERCC2 SNPs and OS. These findings may help in predicting CIN in Thai cancer patients.
8 months ago
Journal
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ERCC1 (Excision repair cross-complementation group 1) • ERCC2 (Excision repair cross-complementation group 2) • EPHX1 (Epoxide Hydrolase 1) • SLC22A2 (Solute Carrier Family 22 Member 2)
The validation of these markers at both the mRNA and protein levels underscores their clinical relevance in ATC diagnosis and tumor characterization. These findings provide a foundation for future biomarker-driven diagnostic and therapeutic strategies for ATC.
Lung cancer incidence and prognosis vary significantly among Hispanics due to their diverse genetic ancestry. Understanding ancestry-specific genetic variations may help personalize treatment and improve outcomes for this population.
11 months ago
Review • Journal
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CYP1A2 (Cytochrome P450, family 1, subfamily A, polypeptide 2) • XRCC1 (X-Ray Repair Cross Complementing 1) • CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) • EPHX1 (Epoxide Hydrolase 1)
Given the targeting potential, this work screens Bezafibrate to block the interaction between TRIM21 and EPHX1 and validates its sensitizing effect. In summary, TRIM21 promotes tumour growth and gemcitabine resistance in PC by inhibiting EPHX1-mediated arachidonic acid metabolism. This provides a novel and promising target for clinical treatment of PC.
EPHX4 promoted the malignant phenotype of CRC cells. Our study firstly elucidated the prognostic significance of EPHX family members in CRC and identified novel diagnostic and prognostic biomarkers for CRC.
1 year ago
Journal • IO biomarker
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PD-L1 (Programmed death ligand 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • EPHX1 (Epoxide Hydrolase 1)
Whole genome DNA sequencing revealed a higher frequency of T > G (A > C) base substitution mutations in worms expressing human CYP1A1;EPHX which aligned with an increase in DNA adducts identified via an ELISA method (but not classical 32P-postlabelling). Overall, the CYP-humanised worms provided new insights into the value of genome-optimised invertebrate models by identifying the benefits and limitations within the context of the (3Rs) concept which aims to replace, reduce and refine the use of animals in research.
1 year ago
Journal
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CYP1A2 (Cytochrome P450, family 1, subfamily A, polypeptide 2) • CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) • EPHX1 (Epoxide Hydrolase 1)
Eight Gln metabolism-related genes were identified as potential biomarkers of AML to predict prognostic risk. The molecular subtypes clustered by these genes enabled prognostic risk stratification.
over 1 year ago
Journal
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EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) • CALR (Calreticulin) • EPHX1 (Epoxide Hydrolase 1) • PDHA1 (Pyruvate Dehydrogenase E1 Subunit Alpha 1) • ANGPTL3 (Angiopoietin Like 3)
We further performed multiple validation of the above DEGs/DEPs using fluorescence quantitative PCR (qPCR), parallel reaction monitoring (PRM), immunohistochemistry, and immunoblotting to confirm the reliability of the multi-omics study. The functions of these DEGs/DEPs were further explored and analyzed, providing a theoretical basis for the mechanism of nerve damage caused by benzene exposure.
over 1 year ago
Preclinical • Journal
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GSTM1 (Glutathione S-transferase mu 1) • EPHX1 (Epoxide Hydrolase 1)