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GENE:

EPHB1 (EPH Receptor B1)

News alerts, weekly reports and conference planners

2ms

Mutational Spectrum of T-Cell Large Granular Lymphocytic Leukemia: Insights From the AACR Project GENIE Consortium. (PubMed, Cancer Genomics Proteomics)

This study provides a comprehensive genomic profile of T-LGLL, identifying recurrent somatic mutations and commonly affected pathways. Notably, frequent alterations were observed in the FAS-FASL signaling pathway, underscoring its potential as a target for therapeutic development.

2 months ago

Retrospective data • Journal

EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • DNMT3A (DNA methyltransferase 1) • KMT2D (Lysine Methyltransferase 2D) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • STAT3 (Signal Transducer And Activator Of Transcription 3) • FASLG (Fas ligand) • IKZF3 (IKAROS Family Zinc Finger 3) • TNFAIP3 (TNF Alpha Induced Protein 3) • EPHB1 (EPH Receptor B1) • SETD1B (SET Domain Containing 1B, Histone Lysine Methyltransferase) • STAT2 (Signal transducer and activator of transcription 2) • ALOX12B (Arachidonate 12-Lipoxygenase) • DDX3X (DEAD-Box Helicase 3 X-Linked)

TP53 mutation • STAT3 mutation

4ms

Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors. (PubMed, Front Mol Neurosci)

The dualistic nature of Eph/ephrin signaling underscores its translational promise as both a biomarker framework and a precision-guided therapeutic target. Combinatorial receptor-ligand modulation strategies may advance the treatment of central nervous system malignancies by exploiting the context-dependent roles of Eph/ephrin interactions.

4 months ago

Review • Journal

ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • EPHA2 (EPH receptor A2) • EPHA3 (EPH receptor A3) • EPHB1 (EPH Receptor B1) • EFNA1 (Ephrin A1) • EFNA5 (Ephrin A5) • EPHA4 (EPH Receptor A4)

6ms

Analgesic effects of electroacupuncture via the EphBs-p38 MAPK signaling pathway and microglial suppression in the chronic constriction injury rat model of neuropathic pain. (PubMed, Acupunct Med)

The analgesic effects of EA in this rat model of NP appear to be linked to diminished p-p38 MAPK expression and subsequent microglial deactivation. EA has a potential role as a complementary therapy for NP.

6 months ago

Preclinical • Journal • IO biomarker

TNFA (Tumor Necrosis Factor-Alpha) • BAX (BCL2-associated X protein) • EPHB1 (EPH Receptor B1)

7ms

Tissue microarray and liquid biopsy approaches identify EphB3, cMet, and miR-3168 as biomarkers of colorectal cancer. (PubMed, Cell Cycle)

These findings highlight the potential of EphB3 and cMet as biomarkers in CRC, and miR-3168 as a promising minimally-invasive biomarker for monitoring disease progression and therapeutic response. However, further validation in larger cohorts is needed to establish their clinical utility.

7 months ago

Journal • Liquid biopsy

EPHB4 (EPH receptor B4) • EPHB1 (EPH Receptor B1) • EPHB3 (EPH Receptor B3) • LGR5 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 5)

7ms

Compressive Force Induces Differential Gene and Protein Expression in Uterine Fibroids. (PubMed, F S Sci)

Compressive forces must be considered to study some of the important differences between fibroids and myometrium, including ephrin signaling. Enrichment analysis of the proteins with different abundances suggests that compression may also be involved in fibroid tumor initiation.

7 months ago

Journal

EPHB1 (EPH Receptor B1) • MMP1 (Matrix metallopeptidase 1)

8ms

EPHB1 Protein Promoted the Progression of Prostate Adenocarcinoma Through Phosphorylating GSK3B and Activating EPHB1-GSK3B-SMAD3 Pathway. (PubMed, Hum Mutat)

Importantly, GSK3B and EPHB1 knockdown inhibited p-SMAD3 activation and promoted proapoptotic features, accompanied by a reduction in macrophage M2 polarization. This study revealed that EPHB1 plays a pivotal role in activating the EPHB1-GSK3B-SMAD3 pathway to facilitate PRAD progression.

8 months ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • KIF13A (Kinesin Family Member 13A) • EPHB1 (EPH Receptor B1) • SMAD3 (SMAD Family Member 3)

8ms

Somatic IRF4 Mutations and Thymic Tropism in Primary Mediastinal Large B-cell Lymphoma. (PubMed, Blood)

IRF4-C99R mutation-induced phenotypes were validated in primary PMBCL tissues using single-nuclei RNA sequencing, confirming that the molecular mechanisms observed in vitro align with the pathophysiology of PMBCL in patients. Together, these findings demonstrate how a single genetic mutation orchestrates the coordinated regulation of hallmark traits including thymus-specific tropism in PMBCL.

8 months ago

Journal

IFNG (Interferon, gamma) • IRF4 (Interferon regulatory factor 4) • PRDM1 (PR/SET Domain 1) • EPHB1 (EPH Receptor B1)

9ms

Calcifying pseudoneoplasm of the neuraxis progressing to G5/PDGFRA subgroup glioblastoma in a United States Army veteran with a history of head trauma and germline POT1 and EPHB2 mutations: illustrative case. (PubMed, J Neurosurg Case Lessons)

This is the first report of CAPNON progression to glioblastoma and of molecularly characterized glioma occurring decades after head trauma. A multifactorial etiology including genetic predisposition and posttraumatic repair is hypothesized. The discussion presents possible roles of EPH RTKs in posttraumatic repair and CAPNON, and of POT1 and PDGFRα in subsequent progression to glioblastoma. https://thejns.org/doi/10.3171/CASE25152.

9 months ago

Journal

CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • DNMT3A (DNA methyltransferase 1) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • EPHB2 (EPH Receptor B2) • POT1 (Protection of telomeres 1) • EPHA7 (EPH Receptor A7) • EPHB1 (EPH Receptor B1) • EPHB3 (EPH Receptor B3)

PDGFRA mutation

temozolomide

10ms

Regulatory role of neuronal guidance proteins in spinal cord injury. (PubMed, Neural Regen Res)

Sema7A is involved in glial scar formation and may influence serotonin channel remodeling, thereby affecting motor coordination. Given these findings, the local or systemic application of neuronal guidance proteins represents a promising avenue for spinal cord injury treatment.

10 months ago

Journal

CASP3 (Caspase 3) • EPHA3 (EPH receptor A3) • SEMA7A (Semaphorin 7A) • EPHB2 (EPH Receptor B2) • EPHA7 (EPH Receptor A7) • EPHB1 (EPH Receptor B1) • SLIT2 (Slit Guidance Ligand 2) • CAPN1 (Calpain 1) • CDH23 (Cadherin Related 23) • EFNA1 (Ephrin A1) • EPHB3 (EPH Receptor B3) • NTN1 (Netrin 1) • SEMA3A (Semaphorin 3A) • SEMA4D (Semaphorin 4D)

10ms

Recurrence Prediction by Multi-Omics in the Patient with Colorectal Peritoneal Metastases After Cytoreductive Surgery: A Prospective Biomarker Study. (PubMed, Cancer Manag Res)

Dynamic ctDNA and methylation monitoring, and tumor mutation profiling, may serve as sensitive biomarkers for early recurrence detection in CRCPM underwent CRS. These tools could enhance recurrence prediction and guide clinical management.

10 months ago

Journal

EPHB1 (EPH Receptor B1)

11ms

Disruption of Ephb1 causes reduced hypothalamic CRH and TRH expression and obesity in mice. (PubMed, Obesity (Silver Spring))

EphB1 regulates hypothalamic CRH and TRH expression and promotes energy expenditure in mice.

11 months ago

Preclinical • Journal

EPHB1 (EPH Receptor B1)

11ms

Eph receptors activate myeloid checkpoint receptor LILRB5 to support tumor development. (PubMed, Cancer Immunol Res)

Eph-induced LILRB5 signaling and functions were reversed by LILRB5 blockade. In sum, certain Eph receptors functionally interact with the myeloid checkpoint receptor LILRB5 resulting in bi-directional signaling, and LILRB5 plays an important role in supporting immunosuppressive myeloid cells and sustaining tumor development.

11 months ago

Journal

EPHA7 (EPH Receptor A7) • EPHB1 (EPH Receptor B1)