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    BIOMARKER:

    EP400 mutation

    i
    Other names: EP400, E1A Binding Protein P400, CAGH32, KIAA1498, KIAA1818, TNRC12, P400, Trinucleotide Repeat-Containing Gene 12 Protein, Trinucleotide Repeat Containing 12, P400 KDa SWI2/SNF2-Related Protein, E1A-Binding Protein P400, CAG Repeat Protein 32, Domino Homolog, HDomino(P400), DKFZP434I225, HDomino, P400 SWI2/SNF2-Related Protein
    Entrez ID:
    57634
    2years
    Derivation of Pancreatic Acinar Cell Carcinoma Cell Line HS-1 as a Patient-derived Tumor Organoid. (PubMed, Cancer Sci)
    Although resistant to standard cytotoxic agents, the cell line was highly sensitive to the proteasome inhibitor bortezomib, as revealed by an in vitro drug screen and in vivo validation. Summarily, we document a novel ACC cell line, which could be useful for ACC studies in the future.
    Preclinical • Journal
    |
    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • EP400 (E1A Binding Protein P400) • SYP (Synaptophysin)
    |
    CDKN2A deletion • EP400 mutation
    |
    bortezomib