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    GENE:

    ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5)

    i
    Other names: ENTPD5, Ectonucleoside Triphosphate Diphosphohydrolase 5 (Inactive), NTPDase-5, CD39L4, PCPH, Ectonucleoside Triphosphate Diphosphohydrolase 5, Nucleoside Diphosphate Phosphatase ENTPD5, Inosine Diphosphate Phosphatase ENTPD5, Guanosine-Diphosphatase ENTPD5, Uridine-Diphosphatase ENTPD5, Nucleoside Diphosphatase, CD39 Antigen-Like 4, Proto-Oncogene CPH, GDPase ENTPD5, UDPase ENTPD5, ER-UDPase, NTPDase 5, Pcph Proto-Oncogene Protein, CD39-Like 4
    Associations

    News

    Trials
    11d
    Purinergic signal transduction and metabolic regulation by ENTPD5 and ENTPD6. (PubMed, Front Endocrinol (Lausanne))
    We review the sometimes conflicting evidence from experimental animal models and propose potential future clinical applications. This review offers insights into the roles of this distinct duo of ENTPD family members to support future basic and translational research in this field.
    Review • Journal
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    ENTPD1 (Ectonucleoside Triphosphate Diphosphohydrolase 1) • ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5)
    4ms
    Developing prognostic models for cholesterol-related genes linked with immune infiltration in prostate cancer. (PubMed, Front Genet)
    The Gleason score of the high-risk group showed a significant difference from that of the low-risk group after clinical data analysis (P < 0.05). The prognostic risk model and nomogram constructed based on the immune-cholesterol-related genes had a great prognostic performance for prostate cancer.
    Journal
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    CD4 (CD4 Molecule) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • UBQLN4 (Ubiquilin 4) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5)
    almost2years
    Uracil as a biomarker for spatial pyrimidine metabolism in the development of gingivobuccal oral squamous cell carcinoma. (PubMed, Sci Rep)
    Furthermore, higher uracil levels were detected in patients with lymph node metastasis, indicating that metastatic potential is increased in the presence of uracil. The presence of uracil and/or expression patterns of intermediate molecules in purine and pyrimidine pathways, such asCD39, CD73, and P2Y6 receptors together with ENTPD4 and ENTPD5, hold promise as biomarker(s) for oral cancer diagnosis and prognosis.
    Journal
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    CD73 (5'-Nucleotidase Ecto) • ENTPD1 (Ectonucleoside Triphosphate Diphosphohydrolase 1) • ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5)
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    CD73 expression
    over2years
    CHRDL1, NEFH, TAGLN and SYNM as novel diagnostic biomarkers of benign prostatic hyperplasia and prostate cancer. (PubMed, Cancer Biomark)
    We found four new diagnostic markers of BPH and PCa, which may facilitate the early diagnosis, treatment, and immunotherapeutic responses assessment and may be of major value in guiding clinical practice.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • GSTP1 (Glutathione S-transferase pi 1) • GPR160 (G Protein-Coupled Receptor 160) • NEFH (Neurofilament Heavy) • TAGLN (Transgelin) • FLNC (Filamin C) • ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5)