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    CANCER:

    Endometrial Cancer

    Related cancers:
    17h
    ECMS: Endometrial Cancer Microbiome Study (ACTRN12623001362684)
    P=N/A, N=260, Recruiting, Te Whatu Ora | Not yet recruiting --> Recruiting
    Enrollment open
    1d
    Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=130, Recruiting, Sairopa B.V. | N=90 --> 130 | Trial completion date: Dec 2025 --> Jul 2027 | Trial primary completion date: Dec 2025 --> May 2027
    Enrollment change • Trial completion date • Trial primary completion date
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    Keytruda (pembrolizumab) • ADU-1805
    1d
    A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia (clinicaltrials.gov)
    P2, N=30, Not yet recruiting, University of Florida | Initiation date: Nov 2025 --> Mar 2026
    Trial initiation date
    3d
    FABP7 Enhances Endometrial Cancer Cell Migration and Stemness by Activating the Wnt/β-catenin Pathway. (PubMed, Biochem Genet)
    Furthermore, FABP7 silencing reduced stemness capacity, as evidenced by diminished sphere-forming ability. Mechanistically, downregulation of FABP7 led to inhibition of the Wnt/β-catenin signaling pathway. This study demonstrates that FABP7 can promote cell migration and stemness in endometrial cancer by activating the Wnt/β-catenin pathway, supporting FABP7 as a potential therapeutic target for the clinical management of endometrial cancer.
    Journal
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    FABP7 (Fatty Acid Binding Protein 7)
    3d
    Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation. (PubMed, Nat Commun)
    Oleic acid-HOXB9-ODC1 stable cascading axis then is confirmed in patient tissues, and ODC1 inhibitors boost patient-derived tumor cells' chemosensitivity. This study links fatty acids to polyamine buildup, reveals a mechanism for metabolic syndrome-driven endometrial cancer, and points to HOXB9 and ODC1 as potential therapeutic targets.
    Journal
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    HOXB9 (Homeobox B9) • ODC1 (Ornithine Decarboxylase 1)
    3d
    The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas (clinicaltrials.gov)
    P2, N=27, Not yet recruiting, Mayo Clinic
    New P2 trial
    3d
    A Study to Investigate GSK5733584 Compared With Chemotherapy in Participants With Recurrent Endometrial Cancer (BEHOLD-Endometrial01) (clinicaltrials.gov)
    P3, N=600, Not yet recruiting, GlaxoSmithKline
    New P3 trial
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    paclitaxel • doxorubicin hydrochloride • mocertatug rezetecan (GSK5733584)
    3d
    Clinicopathological analysis of mesonephric-like adenocarcinoma in the corpusuteri: A report of 3 cases (PubMed, Beijing Da Xue Xue Bao Yi Xue Ban)
    According to the 2023 updated International Federation of Gynecology and Obstetrics (FIGO) staging guidelines for endometrial cancer, all the three cases were in advanced stage. It is suggested that pathologists should make accurate diagnosis based on morphological manifestations, using a set of matched immunohistochemical markers and necessary molecular tests to avoid misdiagnosis and better guide clinical diagnosis and treatment.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • ER (Estrogen receptor) • PGR (Progesterone receptor) • NKX2-1 (NK2 Homeobox 1) • MME (Membrane Metalloendopeptidase) • GATA3 (GATA binding protein 3) • PAX2 (Paired Box 2) • PAX8 (Paired box 8)
    3d
    Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data. (PubMed, BMC Med)
    We observed moderate-to-weak evidence supporting causal effects of alcohol consumption on risk of head/neck, oesophageal, and colorectal cancer, inconsistent evidence for liver cancer, and no evidence for breast cancer. Overall, human genetic data do not provide evidence that alcohol consumption is a cause of all cancers and suggest there may even be inverse associations with certain cancer types.
    Journal
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    ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide)
    3d
    Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer (clinicaltrials.gov)
    P3, N=255, Not yet recruiting, National Cancer Institute (NCI) | Initiation date: Dec 2025 --> Mar 2026
    Trial initiation date • pMMR
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    TP53 mutation
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    Keytruda (pembrolizumab) • Avastin (bevacizumab) • carboplatin • paclitaxel • Aybintio (bevacizumab biosimilar) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn)
    4d
    Letrozole as Maintenance Therapy for Post-surgical Endometrial Cancer Patients With NSMP (clinicaltrials.gov)
    P2/3, N=12, Terminated, Fudan University | N=299 --> 12 | Trial completion date: Jul 2030 --> Dec 2025 | Recruiting --> Terminated | Trial primary completion date: Aug 2028 --> Dec 2025; No enough participants
    Enrollment change • Trial completion date • Trial termination • Trial primary completion date • Head-to-Head
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    letrozole