Endocrine Cancer

To ensure the reliability and generalizability of genetic alterations detected by WES, additional PRSCC samples, along with cell and animal experiments, are warranted to confirm the role of these genetic variants (particularly HYDIN) in PRSCC pathogenesis. The functional role of HYDIN mutations in PRSCC pathogenesis requires further validation in future research.

This case illustrates an exceptionally rare MiNEN of the EGJ with enteroblastic differentiation and morphologic-immunophenotypic discordance. Despite the presence of aggressive histologic features, long-term disease-free survival was achieved with surgical resection alone. This report highlights the importance of thorough histopathological and immunohistochemical evaluation for accurate diagnosis and suggests that curative surgery alone may provide durable disease control in carefully selected patients with localized disease.

The two modalities are mutually reinforcing and hold promise for advancing the precision diagnosis and clinical translation of DLL3-targeted strategies in NENs. This review summarizes recent key advancements in DLL3-targeted nuclear medicine and discusses future directions for DLL3 ImmunoPET imaging and TRT.

Definitive diagnosis relies on pathological examination. Radical surgical resection is an effective treatment.

These findings differentiate biological from artifactual fragmentation, broaden our understanding of high cfDNA levels and hyperfragmentation in cancer, and establish long-read sequencing as a robust tool for biomarker discovery.

P=N/A, N=21, Recruiting, Shanghai Jiao Tong University School of Medicine | Trial completion date: Dec 2025 --> Jun 2027 | Trial primary completion date: Jun 2025 --> Dec 2026

P2, N=23, Not yet recruiting, Beijing GoBroad Hospital

SPECT/CT localized this unexpected uptake to the CBT, representing a rare false-positive finding. This case underscores the importance of correlating functional imaging with structural imaging to avoid misinterpretation of nonspecific radioiodine uptake as metastatic disease and prevent unnecessary therapeutic interventions.

The persistently rising CEA prompted a repeat colonoscopy, upper gastrointestinal and small bowel investigation and a CT of the abdomen and pelvis, without any cause being found. Finally, a CT-positron emission tomography scan revealed localised uptake in the thyroid gland, with a fine-needle aspiration confirming a diagnosis of medullary cell thyroid carcinoma with regional lymph node involvement.

Collectively, these data define a hybrid metabolic phenotype bridging features of small and non-small cell lung cancer while revealing unique metabolic signatures of LCNEC. The resulting atlas provides a foundational resource for biomarker discovery and the development of metabolism-based therapeutic strategies in this understudied lung cancer subtype.

P1, N=40, Recruiting, Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.

P2, N=34, Recruiting, Sun Yat-sen University