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    GENE:

    ELF3 (E74 Like ETS Transcription Factor 3)

    i
    Other names: ELF3, E74 Like ETS Transcription Factor 3, ESE-1, ERT, E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific ), Epithelium-Specific Ets Transcription Factor 1, ETS-Related Transcription Factor Elf-3, Epithelial-Restricted With Serine Box, Epithelium-Restricted Ets Protein ESX, EPR-1, ESX, E74-Like Factor 3 (ETS Domain Transcription Factor, Serine Box, Epithelial-Specific), Ets Domain Transcription Factor, Serine Box (Epithelial-Specific), E74-Like Factor 3 (Ets Domain Transcription Factor), E74-Like Factor 3, ELF3, JEN
    7d
    FKBP10 promotes M2 polarization of macrophage via MEK/ERK/CXCL8 axis and facilitates tumor progression in clear cell renal cell carcinoma. (PubMed, Int J Biol Sci)
    Furthermore, targeting FKBP10 synergized with anti-PD-1 therapy in suppressing tumor growth in vivo. Our work provides a comprehensive molecular atlas of the ccRCC ecosystem, establishes FKBP10 as a key regulator of immune suppression, and highlights its potential as a therapeutic target for personalized immunotherapy.
    Journal
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    CXCL8 (Chemokine (C-X-C motif) ligand 8) • ELF3 (E74 Like ETS Transcription Factor 3) • FKBP10 (FKBP Prolyl Isomerase 10)
    1m
    Single-Cell Regulatory Network Analysis Identifies Adjunctive Drug Candidates in Early Risankizumab-Treated Psoriasis. (PubMed, Curr Pharm Des)
    These findings offer preliminary clues for future risankizumab-based combination strategies in psoriasis.
    Journal
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    CD4 (CD4 Molecule) • S100A8 (S100 Calcium Binding Protein A8) • S100A9 (S100 Calcium Binding Protein A9) • ELF3 (E74 Like ETS Transcription Factor 3) • KRT14 (Keratin 14) • MAFB (MAF BZIP Transcription Factor B) • KRT6A (Keratin 6A) • NFIC (Nuclear Factor I C) • SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1)
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    Jingzhuda (entinostat) • simvastatin
    1m
    Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)
    The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.
    Journal
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    TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)
    1m
    Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer. (PubMed, Cancer Cell)
    Although rare, neuroendocrine GBC was separately characterized, revealing MEIS1 as a potential regulator of neuroendocrine-like features. Together, this study establishes a proteogenomic landscape of GBC, providing biological insights and guiding future translational efforts.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • TP53 (Tumor protein P53) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • MEIS1 (Meis Homeobox 1) • ELF3 (E74 Like ETS Transcription Factor 3) • ACAT1 (Acetyl-CoA Acetyltransferase 1) • PHGDH (Phosphoglycerate Dehydrogenase)
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    TP53 mutation • HER-2 amplification • HER-2 mutation
    2ms
    Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors. (PubMed, Elife)
    Moreover, ELF3 emerged as a core transcription factor regulating LP genes, leading to LP expansion. Our findings suggest that replication stress is a driving factor during BRCA1-associated tumorigenesis in luminal progenitor cells and elucidates the key role of ELF3 during this process.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • ELF3 (E74 Like ETS Transcription Factor 3)
    2ms
    Evolution of the Spatial transcriptomic landscape during the progression of high-grade pancreatic intraductal papillary mucinous neoplasms to invasive cancer. (PubMed, Pancreatology)
    Our study integrates multiple computational approaches for spatial transcriptomics to identify ELF3/MYC/KLF4 amplifications during IPMN-to-PDAC progression, as well as 7 heterogeneous subclones with functions including hypoxia and EMT, alongside immune-stromal landscape remodeling and tumor-adjacent myofibroblastic CAF enrichment.
    Journal
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    CD4 (CD4 Molecule) • KLF4 (Kruppel-like factor 4) • ELF3 (E74 Like ETS Transcription Factor 3)
    2ms
    ETS Family Transcription Factors in Gastric Cancer and the Role of ELF3 in the Core Metaplasia Transcription Factor Network. (PubMed, Oncol Res)
    Cancers with high co-expression of ELF3 and HNF4A were frequently chromosomally instability (CIN), intestinal-type adenocarcinomas, and harbored TP53 mutations and WWOX deletions. Expression of E74 like ETS transcription factor 3 (ELF3), an ETS transcription family member, correlates with expression of other key factors in gastric cancer and confers specific characteristics that may become exploited in targeted therapeutic interventions.
    Journal
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    TP53 (Tumor protein P53) • GATA6 (GATA Binding Protein 6) • TCF3 (Transcription Factor 3) • CDX2 (Caudal Type Homeobox 2) • ELF3 (E74 Like ETS Transcription Factor 3) • ELF1 (E74 Like ETS Transcription Factor 1) • HNF1A (HNF1 Homeobox A) • WWOX (WW Domain Containing Oxidoreductase)
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    TP53 mutation
    3ms
    Transcriptomic insights into GSDME-driven pyroptosis in head and neck cancer. (PubMed, Sci Rep)
    GSDME is potentially associated with the ETS transcription factor ELF3 and the Homeobox transcription factor PBX1. The reduced expression of CK13 and CK19 in the GSDME-overexpressing group may serve as a potential mechanism by which GSDME inhibits HNSCC growth.
    Journal
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    TP53 (Tumor protein P53) • PBX1 (PBX Homeobox 1) • CASP8 (Caspase 8) • ELF3 (E74 Like ETS Transcription Factor 3) • KRT19 (Keratin 19) • NLRP3 (NLR Family Pyrin Domain Containing 3) • GSDME (Gasdermin E)
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    TP53 mutation
    3ms
    ELF3-AS1 promotes the carcinogenesis of hepatocellular carcinoma cells by inhibiting miR-98-5p/CPSF4 axis. (PubMed, Nucleosides Nucleotides Nucleic Acids)
    In addition, miR-98-5p can bind ELF3-AS1 and CPSF4 and down-regulate the expression of CPSF4. In summary, ELF3-AS1 promotes the proliferation, migration, and invasion of HCC cells by inhibiting miR-98-5p/CPSF4 axis.
    Journal
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    ELF3 (E74 Like ETS Transcription Factor 3) • MIR98 (MicroRNA 98)
    3ms
    Identification and Validation of Tumorigenesis Related Hub Genes in Hepatocellular Carcinoma via Integrated Bioinformatics Analysis. (PubMed, Iran J Biotechnol)
    The study underscores the importance of cirrhosis in HCC progression and highlights the PI3K-Akt pathway's pivotal role. Further functional validation and larger cohort studies are warranted.
    Journal
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    ELF3 (E74 Like ETS Transcription Factor 3) • RPL8 (Ribosomal Protein L8)
    4ms
    Advancements in single-cell sequencing for cervical cancer research. (PubMed, Mol Cell Biochem)
    Future efforts must prioritize functional validation of novel targets (DKK2, ELF3), spatial multi-omics to resolve CAF-immune-metabolic crosstalk, and biomarker-driven clinical trials integrating single-cell classifiers. By bridging single-cell insights with mechanistic and translational studies, the field can overcome stromal-mediated resistance and usher in an era of precision immunotherapy for CC.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
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    ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • NRG1 (Neuregulin 1) • LAG3 (Lymphocyte Activating 3) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • SPP1 (Secreted Phosphoprotein 1) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • ELF3 (E74 Like ETS Transcription Factor 3) • SALL4 (Spalt Like Transcription Factor 4) • PODXL (Podocalyxin) • PCLAF (PCNA Clamp Associated Factor)
    4ms
    Single-cell transcriptomic analysis reveals epithelial and microenvironmental heterogeneity in small cell carcinoma of the esophagus. (PubMed, Front Immunol)
    Our single-cell atlas offers a detailed view of the cellular heterogeneity and microenvironmental complexity of SCCE, highlighting its distinct tumor architecture, immune exclusion, and stromal reprogramming. These findings provide a valuable resource for understanding SCCE biology and form a basis for future mechanistic and exploratory biological investigations.
    Journal
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    ELF3 (E74 Like ETS Transcription Factor 3)