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    BIOMARKER:

    ELF3 mutation

    i
    Other names: ELF3, E74 Like ETS Transcription Factor 3, ESE-1, ERT, E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific ), Epithelium-Specific Ets Transcription Factor 1, ETS-Related Transcription Factor Elf-3, Epithelial-Restricted With Serine Box, Epithelium-Restricted Ets Protein ESX, EPR-1, ESX, E74-Like Factor 3 (ETS Domain Transcription Factor, Serine Box, Epithelial-Specific), Ets Domain Transcription Factor, Serine Box (Epithelial-Specific), E74-Like Factor 3 (Ets Domain Transcrip
    Entrez ID:
    1999
    Related biomarkers:
    Others
    Associations

    News

    Trials
    over1year
    ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway. (PubMed, J Pathol)
    RNA sequencing showed upregulated expression of epiregulin (Ereg) in KPCE organoids, and western blotting revealed that EGFR/mechanical targets of rapamycin complex 1 (mTORC1) were upregulated in KPCE organoids..
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • EREG (Epiregulin) • TCF3 (Transcription Factor 3) • ELF3 (E74 Like ETS Transcription Factor 3) • PDX1 (Pancreatic And Duodenal Homeobox 1)
    |
    ELF3 mutation
    |
    sirolimus
    over2years
    Identification of the gene expression changes and gene regulatory aspects in ELF3 mutant bladder cancer. (PubMed, Mol Biol Rep)
    Our results provide important insights about how ELF3 mutation contributes to bladder tumorigenesis and uncover previously unknown dependencies.
    Journal
    |
    ELF3 (E74 Like ETS Transcription Factor 3) • PIK3C2B (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta)
    |
    ELF3 mutation