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BIOMARKER:

ELAVL1 expression

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Other names: ELAVL1, ELAV Like RNA Binding Protein 1, ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R), Embryonic Lethal, Abnormal Vision, Drosophila, Homolog-Like 1, ELAV-Like Protein 1, Hu Antigen R, Hu-Antigen R, HUR
Entrez ID:
2ms
ELAVL1 regulates glycolysis in nasopharyngeal carcinoma cells through the HMGB3/β-catenin axis. (PubMed, Mol Med)
ELAVL1 promotes glycolysis in nasopharyngeal carcinoma cells by interacting with HMGB3 to stabilize HMGB3 mRNA, thereby activating β-catenin pathway. Therefore, targeting the ELAVL1-HMGB3-β-catenin axis has the potential to be a novel approach for treating nasopharyngeal carcinoma.
Journal
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CTNNB1 (Catenin (cadherin-associated protein), beta 1) • ELAVL1 (ELAV Like RNA Binding Protein 1)
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ELAVL1 expression
3ms
ELAVL1 regulates PD-L1 mRNA stability to disrupt the infiltration of CD4-positive T cells in prostate cancer. (PubMed, Neoplasia)
In addition, androgen receptor (AR) was shown to be regulated with ELAVL1, and knocking down AR could also affect the expression of PD-L1. Therefore, ELAVL1 can directly or indirectly regulate the expression of PD-L1, thereby affecting the infiltration of CD4-positive T cells in PCa and ultimately leading to immune suppression.
Journal • PD(L)-1 Biomarker • IO biomarker
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AR (Androgen receptor) • CD4 (CD4 Molecule) • ELAVL1 (ELAV Like RNA Binding Protein 1)
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PD-L1 expression • ELAVL1 expression • CD4 positive
11ms
Molecular landscape of proliferative verrucous leukoplakia: a systematic review. (PubMed, Br J Oral Maxillofac Surg)
PVL stroma shows significantly lower α-SMA and higher CD34 expression than OVC and OSCC. The exact genomic landscape is currently unclear, and further studies are necessary to unravel this mystery.
Review • Journal
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TP53 (Tumor protein P53) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CD34 (CD34 molecule) • ELAVL1 (ELAV Like RNA Binding Protein 1) • CTTN (Cortactin) • SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit)
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TP53 mutation • CDKN2A mutation • TP53 expression • ELAVL1 expression
1year
Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction. (PubMed, Cancer Gene Ther)
Moreover, the depletion of circRHBDD1 notably increased ferroptotic cell death and enhanced RSL3-induced ferroptosis in CRC cells...Finally, circRHBDD1 knockdown repressed the tumorigenesis and ferroptosis of CRC cells in vivo. In conclusion, circRHBDD1 facilitates tumour progression and obstructs ferroptosis in CRC by regulating SCD expression in an ELAVL1-dependent manner.
Journal
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ELAVL1 (ELAV Like RNA Binding Protein 1) • SCD (Stearoyl-CoA Desaturase)
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ELAVL1 expression
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RSL3
1year
Knock out of ELAVL1 affects steroid synthesis in a​​​​​​​​drenocortical carcinoma cell line NCI-H295R and leads to a less malignant phenotype (DGHO 2023)
Our study showed that ELAVL1 affects the regulation of around 7000 genes in the ACC cell line NCI-H295R. Especially the inhibition of glucocorticoid synthesis shows that ELAVL1 may be a new target for therapeutic approaches in ACC treatment since hypercortisolism is one of the main symptoms in ACC and a negative prognostic factor for patient survival.
Preclinical
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CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • CYP1A2 (Cytochrome P450, family 1, subfamily A, polypeptide 2) • ELAVL1 (ELAV Like RNA Binding Protein 1)
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ELAVL1 expression
over1year
RELATIONSHIP AND CELLULAR LOCALIZATION OF AHR AND ELAVL1 IN PANCREATIC CANCER, IN VITRO (UEGW 2023)
In such cases, gemcitabine remains one the first-line drugs used for treatment [2] but the efficacy of the treatment can fall short due to PDAC tumour heterogeneity and its acquired resistance to said chemotherapy [3]... A direct relationship between AHR and ELAVL1 can be seen in PDAC. Moreover, by decreasing AHR expression it is possible to increase ELAVL1 shuttling from nucleus to cytoplasm which might contribute to PDAC cells responding better to chemotherapy.
Preclinical
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AHR (Aryl hydrocarbon receptor) • ELAVL1 (ELAV Like RNA Binding Protein 1)
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AHR expression • ELAVL1 expression
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gemcitabine
over1year
Proteomic profiling and ROC analysis identify CD151 and ELAVL1 as potential therapy response markers for the antiviral drug in resistant TNBC. (PubMed, Life Sci)
ROC analysis predicted and validated CD151 and ELAVL1 as best therapy response marker for TAU in TNBC. These findings provide new insight into repurposing antiviral drug TAU for treatment of metastatic and drug resistant TNBC.
Journal
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SOX2 • CD24 (CD24 Molecule) • POU5F1 (POU Class 5 Homeobox 1) • ELAVL1 (ELAV Like RNA Binding Protein 1)
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CD44 expression • CD24 expression • ELAVL1 expression
2years
Downregulation of ELAVL1 attenuates ferroptosis-induced neuronal impairment in rats with cerebral ischemia/reperfusion via reducing DNMT3B-dependent PINK1 methylation. (PubMed, Metab Brain Dis)
ELAVL1 plays a critical role in protecting against ferroptosis-induced cerebral I/R and subsequent brain damage via DNMT3B/PINK1 axis, thus providing a new potential target for ischemic stroke treatment.
Preclinical • Journal
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GPX4 (Glutathione Peroxidase 4) • DNMT3B (DNA Methyltransferase 3 Beta) • SLC7A11 (Solute Carrier Family 7 Member 11) • ELAVL1 (ELAV Like RNA Binding Protein 1) • PINK1 (PTEN Induced Kinase 1)
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SLC7A11 expression • ELAVL1 expression
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RSL3
2years
circ-WHSC1 affects the growth, metastasis and radiotherapy sensitivity of nasopharyngeal carcinoma cells by targeting miR-338-3p/ELAVL1 axis (PubMed, Zhonghua Zhong Liu Za Zhi)
Circ-WHSC1 regulated the expression of ELAVL1 by targeting miR-382. Knockdown of circ-WHSC1 can inhibit the growth and metastasis of nasopharyngeal carcinoma cells by targeting miR-338-3p/ELAVL1 axis, and enhances the radiosensitivity of nasopharyngeal carcinoma cells.
Journal
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ELAVL1 (ELAV Like RNA Binding Protein 1) • NSD2 (Nuclear Receptor Binding SET Domain Protein 2)
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ELAVL1 expression
over2years
ELAVL1 promotes prostate cancer progression by interacting with other m6A regulators. (PubMed, Front Oncol)
Finally, we found that the dysregulation of ELAVL1 expression occurred in almost all tumors, and interactions between ELAVL1 and other m6A regulators also existed in almost all tumors. In summary, ELAVL1 is an important molecule in the development of PCa, and its interactions with other m6A regulators may play important roles in PCa progression.
Journal
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ELAVL1 (ELAV Like RNA Binding Protein 1)
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ELAVL1 expression
over2years
The RNA-Binding Protein ELAVL1 Regulates Hepatitis B Virus Replication and Growth of Hepatocellular Carcinoma Cells. (PubMed, Int J Mol Sci)
In conclusion, ELAVL1 contributes not only to HBV replication but also to HCC cell growth. It may be a potent therapeutic target for HBV-related HCC treatment.
Journal
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ELAVL1 (ELAV Like RNA Binding Protein 1)
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ELAVL1 expression
3years
Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation, invasion, and 5-fluorouracil resistance. (PubMed, Acta Biochim Biophys Sin (Shanghai))
Mechanistic studies identified that lung cancer cell-derived exosomes activated the PI3K/Akt pathway, and transfection of si-FOXD3-AS1 or treatment with the PI3K inhibitor LY294002 reversed the activation of the PI3K/Akt axis induced by exosomes. In conclusion, our study revealed that lung cancer cell-derived exosomal FOXD3-AS1 upregulated ELAVL1 expression and activated the PI3K/Akt pathway to promote lung cancer progression. Our findings provide a new strategy for lung cancer treatment.
Journal
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ELAVL1 (ELAV Like RNA Binding Protein 1) • FOXD3-AS1 (FOXD3 Antisense RNA 1)
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ELAVL1 expression
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5-fluorouracil • LY294002