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    DRUG CLASS:

    eIF4G1 inhibitor

    Related drugs:
    over2years
    Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition. (PubMed, Sci Rep)
    SBI-756, a small molecule inhibitor of eIF4F assembly, sensitizes human Ph+ and Ph-like B-ALL cells to dasatinib cytotoxicity without affecting survival of T lymphocytes or natural killer cells. These findings support the further evaluation of eIF4F-targeted molecules in combination therapies with TKIs in B-ALL and other blood cancers.
    Journal
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    EIF4G1 (Eukaryotic translation initiation factor 4 gamma, 1)
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    dasatinib • SBI-756