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    BIOMARKER:

    EIF4EBP1 overexpression

    i
    Other names: EIF4EBP1, 4E-BP1, PHAS-I, Eukaryotic translation initiation factor 4E binding protein 1
    Entrez ID:
    1978
    Related biomarkers:
    Expression
    6ms
    mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. (PubMed, Nat Commun)
    Clinically, high EIF4EBP1 expression is associated with poor outcomes in several cancer types. Our data reveal that the mTORC1-4EBP1/2 axis provokes a metabolic switch essential for survival during glucose starvation which is exploited by transformed and tumor cells.
    Journal
    |
    EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) • ACACA (Acetyl-CoA Carboxylase Alpha)
    |
    EIF4EBP1 expression • EIF4EBP1 overexpression
    9ms
    High EIF4EBP1 expression reflects mTOR pathway activity and cancer cell proliferation and is a biomarker for poor breast cancer prognosis. (PubMed, Am J Cancer Res)
    EIF4EBP1 expression did not correlate to a consistent immune system phenotype across all three cohorts. Overall, these findings support that high EIF4EBP1 gene expression in bulk breast tumors could represent a poor prognostic marker via mTOR signaling pathways activation and upregulation of cell cycling, ultimately leading to increased tumorigenesis.
    Journal • Tumor mutational burden
    |
    TMB (Tumor Mutational Burden) • EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1)
    |
    EIF4EBP1 expression • EIF4EBP1 overexpression