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    GENE:

    EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H)

    i
    Other names: EIF3H, Eukaryotic Translation Initiation Factor 3 Subunit H, EIF3-Gamma, EIF3-P40, EIF3S3, Eukaryotic Translation Initiation Factor 3, Subunit 3 Gamma, 40kDa, Eukaryotic Translation Initiation Factor 3 Subunit 3, EIF3 P40 Subunit, EIF-3-Gamma, Eukaryotic Translation Initiation Factor 3, Subunit 3 (Gamma, 40kD), Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD), Eukaryotic Translation Initiation Factor 3, Subunit H, EIF3h
    Associations

    News

    Trials
    2ms
    BE screen reveals METTL3 S2 dephosphorylation sensitizes gastric cancer cells to oxaliplatin by interfering METTL3-eIF3H interaction. (PubMed, Sci Adv)
    In summary, base editor screen provides a versatile approach for exploring the role of phosphorylation sites in cancer chemotherapy. The METTL3-eIF3H interaction may serve as a potential therapeutic target.
    Journal
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    BRD4 (Bromodomain Containing 4) • EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H) • METTL3 (Methyltransferase Like 3)
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    oxaliplatin
    1year
    Deubiquitinating enzymes in breast cancer: in silico analysis of gene expression and metastatic correlation. (PubMed, J Biomol Struct Dyn)
    To identify the role of these genes, EIF3H and COPS5, in disease progression, we constructed a protein-protein interaction (PPI) network with genes associated with metastasis and explored their correlation at the gene expression level in breast cancer patients. Together, this comprehensive study sheds light on DUB gene expression patterns in breast cancer with the potential to identify novel targets for therapeutic interventions.
    Journal • Metastases
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    EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H) • PSMD14 (Proteasome 26S Subunit, Non-ATPase 14)
    almost2years
    The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression. (PubMed, Nat Commun)
    These results uncover the important roles of EIF3H in mediating CRC progression through regulating HAX1 and RAF1-ERK1/2 signaling. EIF3H represents a promising therapeutic target and prognostic marker in CRC.
    Journal
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    MAP2K1 (Mitogen-activated protein kinase kinase 1) • EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H)
    over3years
    EIF3H stabilizes CCND1 to promotes intrahepatic cholangiocarcinoma progression via Wnt/β-catenin signaling. (PubMed, FASEB J)
    Thus, we come to the conclusion that EIF3H promotes proliferation and migration of iCCAs, inhibiting apoptosis of iCCA cells at the same time by stabilizing the CCND1 protein structure. Our findings provide insights into the mechanism of tumorigenesis role of EIF3H in iCCAs and a potential therapeutic target for iCCA treatment.
    Journal
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    CCND1 (Cyclin D1) • EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H)