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EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

News alerts, weekly reports and conference planners

Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice. (PubMed, Nat Commun)

Activation of HSF1 in aged wild-type HSCs partially restores youthful features, supporting a causal role for proteostasis maintenance. Collectively, our findings demonstrate that attenuating MDA5-dependent inflammation preserves HSC function during aging by maintaining metabolic fitness and proteostasis and provide insight into potential therapeutic strategies for mitigating hematopoietic aging.

7 days ago

Preclinical • Journal

EIF2A (Eukaryotic Translation Initiation Factor 2A) • IFIH1 (Interferon Induced With Helicase C Domain 1) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha) • HSF1 (Heat Shock Transcription Factor 1)

Identification of prognostic signatures in pheochromocytomas and paragangliomas based on mitochondrial autophagy and ferroptosis in TCGA and GEO datasets. (PubMed, Discov Oncol)

These findings offer insights into PPGL molecular mechanisms, suggest prognostic biomarkers, and propose candidate therapeutic targets to improve risk stratification and personalized treatment. However, experimental validation is required to confirm their biological relevance before clinical application.

1 month ago

Journal

PHGDH (Phosphoglycerate Dehydrogenase) • AMBRA1 (Autophagy And Beclin 1 Regulator 1) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

2ms

Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia. (PubMed, Chin Med)

These findings reveal that HF exerts anti-leukemic effects by modulating the p-eIF2α-S100A8/A9-Ca2⁺ signaling axis in AML cells. HF represents a promising therapeutic candidate for AML, particularly for patients with IDA-resistant disease.

2 months ago

Journal

S100A8 (S100 Calcium Binding Protein A8) • S100A9 (S100 Calcium Binding Protein A9) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

idarubicin hydrochloride

2ms

USP8-EIF2S1 signaling enhances CML cell survival under TKI-induced stress. (PubMed, FEBS J)

The UPR suppresses general protein translation while promoting the expression of adaptive stress-response genes, allowing CML cells to survive TKI-induced stress. Consequently, targeting the USP8-EIF2S1 axis is proposed as a key therapeutic strategy to overcome resistance and enhance patient outcomes.

2 months ago

Journal

ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

2ms

KCMF1 regulates HRI ubiquitination to inhibit the integrated stress response in ovarian cancer. (PubMed, Biochem Pharmacol)

Plantainoside D was identified as a novel KCMF1 inhibitor that exhibited potent antitumor activity in OC. Overall, KCMF1 regulates HRI ubiquitination to inhibit ISR, thereby promoting tumor growth and progression in OC.

2 months ago

Journal

ATF4 (Activating Transcription Factor 4) • SESN2 (Sestrin 2) • ATF3 (Activating Transcription Factor 3) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

3ms

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response. (PubMed, Nat Commun)

Importantly, low-dose WEE1 inhibition did not induce ISR activation, while it still synergized with PKMYT1 inhibition. Taken together, WEE1i trigger toxic ISR activation and translational shutdown, which can be prevented by low-dose or combination treatments, while retaining the cell cycle checkpoint-perturbing effects.

3 months ago

Journal

ATF4 (Activating Transcription Factor 4) • CDK1 (Cyclin-dependent kinase 1) • EIF2A (Eukaryotic Translation Initiation Factor 2A) • PKMYT1 (Protein Kinase Membrane Associated Tyrosine/Threonine 1) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

4ms

The deubiquitinating enzyme USP8 promotes tyrosine kinase inhibitors resistance in chronic myeloid leukemia by stabilizing EIF2S1 protein. (PubMed, FEBS J)

In summary, our results suggest that USP8 is overexpressed in CML and linked to resistance to TKIs. We have unveiled a previously unknown mechanism of CML drug resistance, which may provide novel perspectives on the advancement of targeted therapeutic strategies and clinical interventions.

4 months ago

Journal

EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

7ms

eIF2A regulates cell migration in a translation-independent manner. (PubMed, Sci Adv)

Interaction with mRNA, however, does not require ongoing translation. These findings reveal a role for eIF2A in centrosome dynamics beyond its traditional function in translation.

7 months ago

Journal

EIF2A (Eukaryotic Translation Initiation Factor 2A) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

7ms

Testing Protein Stress Signals in Peripheral Immunocytes Under the Same Treatment Capable of Decreasing the Incidence of Alzheimer's Disease in Bladder Cancer Patients. (PubMed, Curr Issues Mol Biol)

Higher antiapoptotic scores were observed upon a longer time from BCG treatment (with the exception of the patient in her ninth decade of life). Studies with more individuals could substantiate that BCG enhances the antiapoptotic aggregate-clearance effect of the UPR in PBMCs of NMIBC patients, which hypothetically protects brain cells against AD.

7 months ago

Journal

EIF2A (Eukaryotic Translation Initiation Factor 2A) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

7ms

Sinapic acid induces cytoplasmic stress granule formation, ER stress and apoptosis mediated anticancer activity in human endometrial cancer cell lines. (PubMed, Med Oncol)

TEM analyses also demonstrated that SA induced cytoplasmic stress granule formation in both cell lines. Therefore, this study suggested that SA can be a potential anticancer therapeutic agent for endometrial cancer.

7 months ago

Preclinical • Journal

TP53 (Tumor protein P53) • SERPINH1 (Serpin family H member 1) • FADD (Fas associated via death domain) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • CALR (Calreticulin) • CASP9 (Caspase 9) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ATF6 (Activating Transcription Factor 6) • CASP7 (Caspase 7) • EIF2A (Eukaryotic Translation Initiation Factor 2A) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) • PERK (Pancreatic EIF2-Alpha Kinase) • XBP1 (X-box-binding protein 1) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

8ms

Super-enhancer PPP1R15B/EIF2A axis characterizes aggressive drug-tolerant persister cells in Glioblastoma. (PubMed, Biomed Pharmacother)

The PPP1R15B super-enhancer critically drives the PPP1R15B/EIF2A axis and TMZ resistance in GBM TTPCCs. Targeting this axis may offer a promising therapeutic approach to overcome TMZ resistance.

8 months ago

Journal

EIF2A (Eukaryotic Translation Initiation Factor 2A) • PPP1R15B (Protein Phosphatase 1 Regulatory Subunit 15B) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)

temozolomide

8ms

Differential response of SNU-1826 colon cells on the autophagy, ER stress, and inflammation during the regulation of microplastic internalization. (PubMed, J Toxicol Sci)

Furthermore, the positive correlation was detected between MPs internalization and most parameters for cellular responses although their inhibition is stronger than stimulation. These results suggest that the internalization of MPs into SNU-1826 cells may be strongly associated with the changes in autophagy, ER stress, and inflammation during the regulation of CD and ZnSO4.

8 months ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • BECN1 (Beclin 1) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)