^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    EIF2A (Eukaryotic Translation Initiation Factor 2A)

    i
    Other names: EIF2A, Eukaryotic Translation Initiation Factor 2A, Eukaryotic Translation Initiation Factor 2A 65kDa, 65 KDa Eukaryotic Translation Initiation Factor 2A, EIF-2A, MSTP004, MSTP089, MST089, CDA02
    6d
    Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice. (PubMed, Nat Commun)
    Activation of HSF1 in aged wild-type HSCs partially restores youthful features, supporting a causal role for proteostasis maintenance. Collectively, our findings demonstrate that attenuating MDA5-dependent inflammation preserves HSC function during aging by maintaining metabolic fitness and proteostasis and provide insight into potential therapeutic strategies for mitigating hematopoietic aging.
    Preclinical • Journal
    |
    EIF2A (Eukaryotic Translation Initiation Factor 2A) • IFIH1 (Interferon Induced With Helicase C Domain 1) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha) • HSF1 (Heat Shock Transcription Factor 1)
    3ms
    WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response. (PubMed, Nat Commun)
    Importantly, low-dose WEE1 inhibition did not induce ISR activation, while it still synergized with PKMYT1 inhibition. Taken together, WEE1i trigger toxic ISR activation and translational shutdown, which can be prevented by low-dose or combination treatments, while retaining the cell cycle checkpoint-perturbing effects.
    Journal
    |
    ATF4 (Activating Transcription Factor 4) • CDK1 (Cyclin-dependent kinase 1) • EIF2A (Eukaryotic Translation Initiation Factor 2A) • PKMYT1 (Protein Kinase Membrane Associated Tyrosine/Threonine 1) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)
    7ms
    eIF2A regulates cell migration in a translation-independent manner. (PubMed, Sci Adv)
    Interaction with mRNA, however, does not require ongoing translation. These findings reveal a role for eIF2A in centrosome dynamics beyond its traditional function in translation.
    Journal
    |
    EIF2A (Eukaryotic Translation Initiation Factor 2A) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)
    7ms
    Testing Protein Stress Signals in Peripheral Immunocytes Under the Same Treatment Capable of Decreasing the Incidence of Alzheimer's Disease in Bladder Cancer Patients. (PubMed, Curr Issues Mol Biol)
    Higher antiapoptotic scores were observed upon a longer time from BCG treatment (with the exception of the patient in her ninth decade of life). Studies with more individuals could substantiate that BCG enhances the antiapoptotic aggregate-clearance effect of the UPR in PBMCs of NMIBC patients, which hypothetically protects brain cells against AD.
    Journal
    |
    EIF2A (Eukaryotic Translation Initiation Factor 2A) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)
    7ms
    Sinapic acid induces cytoplasmic stress granule formation, ER stress and apoptosis mediated anticancer activity in human endometrial cancer cell lines. (PubMed, Med Oncol)
    TEM analyses also demonstrated that SA induced cytoplasmic stress granule formation in both cell lines. Therefore, this study suggested that SA can be a potential anticancer therapeutic agent for endometrial cancer.
    Preclinical • Journal
    |
    TP53 (Tumor protein P53) • SERPINH1 (Serpin family H member 1) • FADD (Fas associated via death domain) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • CALR (Calreticulin) • CASP9 (Caspase 9) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ATF6 (Activating Transcription Factor 6) • CASP7 (Caspase 7) • EIF2A (Eukaryotic Translation Initiation Factor 2A) • ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) • PERK (Pancreatic EIF2-Alpha Kinase) • XBP1 (X-box-binding protein 1) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)
    8ms
    Super-enhancer PPP1R15B/EIF2A axis characterizes aggressive drug-tolerant persister cells in Glioblastoma. (PubMed, Biomed Pharmacother)
    The PPP1R15B super-enhancer critically drives the PPP1R15B/EIF2A axis and TMZ resistance in GBM TTPCCs. Targeting this axis may offer a promising therapeutic approach to overcome TMZ resistance.
    Journal
    |
    EIF2A (Eukaryotic Translation Initiation Factor 2A) • PPP1R15B (Protein Phosphatase 1 Regulatory Subunit 15B) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)
    |
    temozolomide
    9ms
    A fermented Mistletoe (Viscum album L.) extract elicits markers characteristic for immunogenic cell death driven by endoplasmic reticulum stress in vitro. (PubMed, BMC Complement Med Ther)
    In this in vitro study, we demonstrated for the first time the potential of a mistletoe extract to induce surrogate markers of immunogenic cancer cell death. This is a primary step in investigating the potential of VAEs to contribute to ICD-induced tumor-specific immune activation.
    Preclinical • Journal • IO biomarker
    |
    HMGB1 (High Mobility Group Box 1) • CALR (Calreticulin) • ATF4 (Activating Transcription Factor 4) • EIF2A (Eukaryotic Translation Initiation Factor 2A) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
    |
    paclitaxel
    10ms
    Loss of non-canonical translation initiation factors impairs perinatal cardiac function in mice. (PubMed, Exp Anim)
    These findings underscore the importance of non-AUG translation initiation in maintaining cardiac function and suggest its broader implications in other physiological and pathological processes. We propose the Eif2a and Eif2d double-knockout mice as a novel stress-sensitive animal model to investigate the molecular mechanisms of translation regulation and their contribution to disease pathogenesis.
    Preclinical • Journal
    |
    EIF2A (Eukaryotic Translation Initiation Factor 2A) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)
    10ms
    Effects of anlotinib hydrochloride on the expression of immunogenic cell death-related molecules in Cal27 tongue cancer cells. (PubMed, Discov Oncol)
    AL3818 has the potential to induce ICD in the Cal27 TSCC cell line by modulating the levels of ICD-related molecules such as ATP, CRT, HSP70, and HMGB1. Moreover, the combination of AL3818 and PTX is more effective in inducing ICD in Cal27 cells compared to either agent alone. The process by which CRT is transferred from within the cell to the membrane during the induction of ICD in the Cal27 cell line by AL3818 may be related to the phosphorylation and activation of the PERK/elF2a signaling pathway.
    Journal
    |
    HMGB1 (High Mobility Group Box 1) • CALR (Calreticulin) • EIF2A (Eukaryotic Translation Initiation Factor 2A) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)
    |
    paclitaxel • Focus V (anlotinib)
    11ms
    Combination of brefeldin A and tunicamycin induces apoptosis in HepG2 cells through the endoplasmic reticulum stress-activated PERK-eIF2α-ATF4-CHOP signaling pathway. (PubMed, Liver Res)
    BFA could induce apoptosis and ER stress, and TM could enhance the ability of BFA to induce apoptosis and ER stress in HepG2 cells through the PERK-eIF2ɑ-ATF4-CHOP pathway. The findings highlight the therapeutic potential of the combined use of BFA and TM in treating HCC.
    Journal • PARP Biomarker
    |
    CASP3 (Caspase 3) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ATF4 (Activating Transcription Factor 4) • CASP12 (Caspase 12 (Gene/Pseudogene)) • EIF2A (Eukaryotic Translation Initiation Factor 2A) • SCD (Stearoyl-CoA Desaturase)
    1year
    Macrocarpal I induces immunogenic cell death and synergizes with immune checkpoint inhibition by targeting tubulin and PARP1 in colorectal cancer. (PubMed, Cell Death Discov)
    Mechanistically, Macrocarpal I directly targets TUBB2B and PARP1, disrupting microtubule polymerization and DNA repair processes. Importantly, treatment with Macrocarpal I enhances the anti-tumor immune response and augments responsiveness to anti-PD-1 therapy in an MC38 syngeneic mouse model of CRC.
    Journal • Checkpoint inhibition
    |
    PARP1 (Poly(ADP-Ribose) Polymerase 1) • ATF4 (Activating Transcription Factor 4) • EIF2A (Eukaryotic Translation Initiation Factor 2A) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)
    over1year
    Cepharanthine Triggers Ferroptosis Through Inhibition of NRF2 For Robust ER Stress Against Lung Cancer. (PubMed, Eur J Pharmacol)
    In summary, our findings proved CEP drives ferroptosis through inhibition of NRF2 for induction of robust ER stress, thereby leading to apoptosis and attenuated stemness of lung cancer cells. The current work presents a novel mechanism for the anti-tumor efficacy of the natural compound CEP.
    Journal
    |
    GPX4 (Glutathione Peroxidase 4) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • EIF2A (Eukaryotic Translation Initiation Factor 2A) • EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha)