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    BIOMARKER:

    EHD1 overexpression

    i
    Other names: EHD1, EH Domain Containing 1, Testilin, HPAST1, EH Domain-Containing Protein 1, PAST Homolog 1, H-PAST, PAST1, PAST, FLJ42622, FLJ44618
    Entrez ID:
    10938
    over2years
    EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis. (PubMed, Commun Biol)
    Conversely, EHD1 overexpression-dependent exaggerated oncogenic traits require IGF-1R expression and kinase activity. Our findings define the RTK traffic regulation as a proximal mechanism of EHD1 overexpression-dependent oncogenesis that impinges on IGF-1R in EWS, supporting the potential of IGF-1R and EHD1 co-targeting.
    Journal
    |
    IGF1 (Insulin-like growth factor 1) • EHD1 (EH Domain Containing 1)
    |
    EHD1 overexpression
    almost4years
    A novel EHD1/CD44/Hippo/SP1 positive feedback loop potentiates stemness and metastasis in lung adenocarcinoma. (PubMed, Clin Transl Med)
    Our findings emphasise that EHD1 might be a potent anti-metastatic target and present a novel regulatory mechanism by which the EHD1/CD44/Hippo/SP1 positive feedback circuit plays pivotal roles in coupling modules of CSCs-like properties and EMT in LUAD. Targeting this loop may serve as a remedy for patients with advanced metastatic LUAD.
    Journal
    |
    CD44 (CD44 Molecule) • EHD1 (EH Domain Containing 1)
    |
    EHD1 overexpression