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DRUG:
EGFR806-specific CAR T-cell therapy
i
Other names: EGFR806-specific chimeric antigen receptor (CAR) T cell therapy, second generation 4-1BBζ EGFR806-EGFRt, EGFR806-specific CAR T-cell therapy
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Our results demonstrates anti-tumor activity of EGFR806 CAR T cells against TNBC cells in vitro and in vivo. Given EGFR806 CAR T cells are currently undergoing clinical trials in primary brain tumor patients without obvious toxicity, our results are immediately actionable against the TNBC-BM patient population.
2 years ago
Journal
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EGFR (Epidermal growth factor receptor)
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EGFR806-specific CAR T-cell therapy • depatuxizumab (ABT-806)