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    BIOMARKER:

    EGFR underexpression

    i
    Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor
    Entrez ID:
    1956
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    9ms
    IBPGNET: lung adenocarcinoma recurrence prediction based on neural network interpretability. (PubMed, Brief Bioinform)
    The knockdown of PSMC1 and PSMD11 in LUAD cells increased their sensitivity to afatinib and decreased cell migration, invasion and proliferation. In addition, the cells showed significantly lower EGFR expression, indicating that PSMC1 and PSMD11 may mediate therapeutic sensitivity through EGFR expression.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • PSMD1 (Proteasome 26S Subunit Non-ATPase 1) • PSMC1 (Proteasome 26S Subunit, ATPase 1)
    |
    EGFR expression • EGFR underexpression
    |
    Gilotrif (afatinib)
    1year
    A Phase II, Open Label Study of ONC201 in Adults With EGFR-low Glioblastoma (clinicaltrials.gov)
    P2, N=0, Withdrawn, Masonic Cancer Center, University of Minnesota | N=36 --> 0 | Not yet recruiting --> Withdrawn
    Enrollment change • Trial withdrawal
    |
    EGFR (Epidermal growth factor receptor)
    |
    EGFR amplification • EGFR expression • EGFRvIII expression • EGFR underexpression
    |
    dordaviprone (ONC201)