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    BIOMARKER:

    EGFR mutation + TP53 mutation + BRCA1 mutation

    i
    Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor, TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1, BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset
    Entrez ID:
    1956; 7157; 672
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over1year
    Co-occurring Alterations in Multiple Tumor Suppressor Genes are Associated with Worse Outcomes in Patients with EGFR-mutant Lung Cancer (IASLC-TTLC 2023)
    The inferior outcomes in patients with EGFR-mutant NSCLC with tumors harboring a co-occurring TP53 mutation may be due to additional TSG alterations rather than TP53 mutational status alone. This may have implications for understanding the biologic underpinnings of differential outcomes to EGFR-TKIs.
    Clinical • BRCA Biomarker
    |
    EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • BRCA1 (Breast cancer 1, early onset) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1) • ARID1A (AT-rich interaction domain 1A) • NF1 (Neurofibromin 1)
    |
    TP53 mutation • EGFR mutation • TP53 wild-type • EGFR mutation + TP53 mutation + ARID1A mutation • EGFR mutation + TP53 mutation + BRCA1 mutation • EGFR mutation + TP53 mutation + NF1 mutation • EGFR mutation + TP53 mutation + PTEN mutation • EGFR mutation + TP53 mutation + RB1 mutation