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    BIOMARKER:

    EGFR G719A + EGFR R776C

    i
    Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor
    Entrez ID:
    1956
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over2years
    Afatinib, an effective treatment for patient with lung squamous cell carcinoma harboring uncommon EGFR G719A and R776C co-mutations. (PubMed, J Cancer Res Clin Oncol)
    This case first identified a patient with lung squamous cell carcinoma harboring uncommon compound EGFR mutation (G719A and R776C) benefited from afatinib and achieved 11 months of progression-free survival (PFS). Then, new MYC amplification was detected after disease progression, indicating that MYC amplification may be one of the reasons for afatinib resistance.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • MYC (V-myc avian myelocytomatosis viral oncogene homolog)
    |
    EGFR mutation • MYC amplification • EGFR L861Q • EGFR G719X • EGFR S768I • EGFR G719A • EGFR G719A + EGFR R776C • EGFR R776C
    |
    Gilotrif (afatinib)