EGFR exon 20 mutation + EGFR V774M + EGFR S768I

The second-generation EGFR-TKI afatinib has been shown to be effective against complex rare EGFR mutations like H773L/V774M or G719X/S768I, meanwhile more adverse effects such as diarrhea and rash occur...Telephone follow-up revealed that the patient continued to take aumolertinib in combination with anlotinib until her death in July 2022... A previous report indicated that patients harboring two uncommon mutations were associated with poorer prognosis (mPFS: 6.5 months). However, the AIM study, recently published in ESMO ASIA 2022, demonstrated that aumolertinib had an impressive objective response rate (ORR) of 53.8% and disease control rate (DCR) of 100% in patients with the main rare mutations (G719X/L861Q/S768I). In summary, this case report suggests that EGFR V774M/S768I can be an activating mutation complex and the administration of aumolertinib monotherapy or a combination with anti-angiogenic drug can achieve outstanding clinical benefits for these patients.