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BIOMARKER:

EGFR exon 19 insertion

i
Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor
Entrez ID:
10ms
NCI-2019-05913: Alisertib in Combination With Osimertinib in Metastatic EGFR-mutant Lung Cancer (clinicaltrials.gov)
P1, N=22, Active, not recruiting, Collin Blakely | Recruiting --> Active, not recruiting | N=38 --> 22 | Trial completion date: Feb 2025 --> May 2025 | Trial primary completion date: Feb 2025 --> May 2025
Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Metastases
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EGFR (Epidermal growth factor receptor) • TPX2 (TPX2 Microtubule Nucleation Factor)
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EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR T790M • EGFR L861Q • EGFR G719X • EGFR S768I • EGFR E709K • EGFR exon 19 insertion • EGFR H835L • EGFR L833V • EGFR V834L
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Tagrisso (osimertinib) • alisertib (MLN8237)
10ms
Molecular Characteristics and Response to TKIs in NSCLC Patients with EGFR Exon 19 Insertions (IASLC-WCLC 2023)
Results from in vitro experiments suggested that the EGFR I740_K745dup mutation might be more sensitive to afatinib. Our comprehensive analysis of EGFR 19ins in lung cancer patients revealed genomic characteristics and clinical response that are distinct from 19del/delins. Our findings help better inform clinical action and might facilitate the development of more precise therapeutic options for patients with these uncommon driver mutations.
Clinical • Tumor mutational burden
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EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden)
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EGFR mutation • PIK3CA mutation • EGFR exon 19 deletion • EGFR T790M • EGFR exon 19 insertion • EGFR E746
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Gilotrif (afatinib)
11ms
EGFR exon 19 insertion EGFR-K745_E746insIPVAIK and others with rare XPVAIK amino-acid insertions: Preclinical and clinical characterization of the favorable therapeutic window to all classes of approved EGFR kinase inhibitors. (PubMed, Lung Cancer)
This is the largest preclinical/clinical report to highlight that EGFR-K745_E746insIPVAIK and other mutations with exon 19 XPVAIK amino-acid insertions are rare but sensitive to clinically available 1st, 2nd, and 3rd generation as well as EGFR exon 20 active TKIs; in a pattern that mostly resembles the outcomes of models with EGFR-L861Q and EGFR-A763_Y764insFQEA mutations. These data may help with the off-label selection of EGFR TKIs and clinical expectations of outcomes when targeted therapy is deployed for these EGFR mutated lung cancers.
Preclinical • Journal
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EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR exon 20 insertion • EGFR L861Q • EGFR A763_Y764insFQEA • EGFR exon 20 mutation • EGFR G719S • EGFR exon 19 deletion + EGFR L861Q • EGFR exon 19 insertion • EGFR E746
|
Tagrisso (osimertinib) • erlotinib • Gilotrif (afatinib) • gefitinib • Conmana (icotinib) • Exkivity (mobocertinib)
1year
NCI-2019-05913: Alisertib in Combination With Osimertinib in Metastatic EGFR-mutant Lung Cancer (clinicaltrials.gov)
P1, N=38, Recruiting, Collin Blakely | Trial completion date: Dec 2023 --> Feb 2025 | Trial primary completion date: Dec 2023 --> Feb 2025
Trial completion date • Trial primary completion date • Combination therapy • Metastases
|
EGFR (Epidermal growth factor receptor) • TPX2 (TPX2 Microtubule Nucleation Factor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR T790M • EGFR L861Q • EGFR G719X • EGFR S768I • EGFR E709K • EGFR exon 19 insertion • EGFR H835L • EGFR L833V • EGFR V834L
|
Tagrisso (osimertinib) • alisertib (MLN8237)
2years
NCI-2019-05913: Alisertib in Combination With Osimertinib in Metastatic EGFR-mutant Lung Cancer (clinicaltrials.gov)
P1, N=38, Recruiting, Collin Blakely | Trial completion date: May 2023 --> Dec 2023 | Trial primary completion date: May 2023 --> Dec 2023
Trial completion date • Trial primary completion date • Combination therapy
|
EGFR (Epidermal growth factor receptor) • TPX2 (TPX2 Microtubule Nucleation Factor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR T790M • EGFR L861Q • EGFR G719X • EGFR S768I • EGFR E709K • EGFR exon 19 insertion • EGFR H835L • EGFR L833V • EGFR V834L
|
Tagrisso (osimertinib) • alisertib (MLN8237)
over2years
Uncommon single and compound EGFR mutations: clinical outcomes of a heterogeneous subgroup of NSCLC. (PubMed, Curr Probl Cancer)
For mutations in exon 18 (not in codon 719) and exon 20 insertions, chemotherapy seems the most effective available option. The addition of immunotherapy to chemotherapy could change this approach in the next future.
Clinical • Clinical data • Journal • IO biomarker
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EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR exon 18 mutation • EGFR exon 19 insertion
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Tagrisso (osimertinib) • Gilotrif (afatinib) • gefitinib
3years
NCI-2019-05913: Alisertib in Combination With Osimertinib in Metastatic EGFR-mutant Lung Cancer (clinicaltrials.gov)
P1, N=38, Recruiting, Collin Blakely | Trial completion date: Sep 2024 --> May 2023 | Trial primary completion date: Sep 2022 --> May 2023
Trial completion date • Trial primary completion date • Combination therapy
|
EGFR (Epidermal growth factor receptor) • TPX2 (TPX2 Microtubule Nucleation Factor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR T790M • EGFR L861Q • EGFR G719X • EGFR S768I • EGFR E709K • EGFR exon 19 insertion • EGFR V834L
|
Tagrisso (osimertinib) • alisertib (MLN8237)
over3years
Stereotactic Body Radiation Therapy (SBRT) in Newly Diagnosed Advanced Staged Lung Adenocarcinoma (Sindas) (clinicaltrials.gov)
P3, N=200, Terminated, Sichuan Provincial People's Hospital | Trial completion date: Dec 2023 --> Aug 2020 | Recruiting --> Terminated | Trial primary completion date: Dec 2021 --> Aug 2020; After interim analysis, IRB recommend termination.
Trial completion date • Trial termination • Trial primary completion date
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR L861Q • EGFR S768I • EGFR G719A • EGFR exon 19 insertion
|
erlotinib • gefitinib
over3years
Stereotactic Body Radiation Therapy (SBRT) in Newly Diagnosed Advanced Staged Lung Adenocarcinoma (Sindas) (clinicaltrials.gov)
P3, N=200, Recruiting, Sichuan Provincial People's Hospital | Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2020 --> Dec 2021
Trial completion date • Trial primary completion date
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR L861Q • EGFR S768I • EGFR G719A • EGFR exon 19 insertion
|
erlotinib • gefitinib
over3years
Stereotactic Body Radiation Therapy (SBRT) in Newly Diagnosed Advanced Staged Lung Adenocarcinoma (Sindas) (clinicaltrials.gov)
P3, N=200, Recruiting, Sichuan Provincial People's Hospital | Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2019 --> Dec 2020
Trial completion date • Trial primary completion date
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR L861Q • EGFR S768I • EGFR G719A • EGFR exon 19 insertion
|
erlotinib • gefitinib
over5years
Local Therapies for Oligometastatic Non-Small Cell Lung Cancer Harboring Sensitizing EGFR Mutations (clinicaltrials.gov)
P=N/A, N=4, Completed, Memorial Sloan Kettering Cancer Center | Recruiting --> Completed | Trial primary completion date: May 2018 --> Dec 2017
Clinical • Trial completion • Trial primary completion date
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR L861Q • EGFR S768I • EGFR G719A • EGFR exon 19 insertion
|
erlotinib
almost7years
Erlotinib Treatment Beyond Progression in EGFR Mutant NSCLC (clinicaltrials.gov)
P2; N=18; Completed; Sponsor: Finnish Lung Cancer Group; Recruiting --> Completed; N=80 --> 18
Enrollment change • Trial completion • Clinical
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EGFR L858R • EGFR L861Q • EGFR G719A • EGFR G719S • EGFR G719C • EGFR exon 19 insertion
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cisplatin • erlotinib • carboplatin • paclitaxel • docetaxel • pemetrexed