^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    EEF2K overexpression

    i
    Other names: EEF2K, Eukaryotic Elongation Factor 2 Kinase, EEF-2K, CaMKIII, EEF-2 Kinase, Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor-2 Kinase, Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase, Calmodulin-Dependent Protein Kinase III, Eukaroytic Elongation Factor 2 Kinase, Elongation Factor-2 Kinase, Alternative Protein EEF2K, HSU93850
    Entrez ID:
    29904
    almost2years
    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis. (PubMed, Mol Cell)
    Finally, FAM86A ablation strongly attenuates tumor growth and extends survival in KRASG12C-driven LUAD mouse models. Thus, our work uncovers an eEF2 methylation-mediated mRNA translation elongation regulatory node and nominates FAM86A as an etiologic agent in LUAD.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • EEF2K (Eukaryotic Elongation Factor 2 Kinase)
    |
    KRAS G12C • KRAS G12 • EEF2K overexpression
    almost4years
    eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma. (PubMed, J Immunother Cancer)
    Our results suggest that eEF2K may serve as a biomarker for predicting therapeutic response and prognosis in patients receiving anti-PD-1 therapy, reveal a vital role of eEF2K in regulating TIME by controlling PD-L1 expression and provide a potential combination therapeutic strategy of eEF2K inhibition with ICB therapy.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • EEF2K (Eukaryotic Elongation Factor 2 Kinase) • GSK3B (Glycogen Synthase Kinase 3 Beta)
    |
    PD-L1 expression • EEF2K overexpression
    almost4years
    Upregulated IncRNA WTAPP1 in Triple Negative Breast Cancer Predicts Survival. (PubMed, Crit Rev Eukaryot Gene Expr)
    In addition, overexpression of miR-34a enhanced the effects of overexpression of WTAPP1 and EEF2K on apoptosis. WTAPP1 may promote TNBC cell proliferation by downregulating miR-34a.
    Journal
    |
    MIR34A (MicroRNA 34a-5p) • EEF2K (Eukaryotic Elongation Factor 2 Kinase) • WTAP (WT1 Associated Protein)
    |
    EEF2K overexpression • miR-34a overexpression