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    GENE:

    EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma)

    i
    Other names: EEF1G, Eukaryotic Translation Elongation Factor 1 Gamma, EF1G, Elongation Factor 1-Gamma, EEF-1B Gamma, EF-1-Gamma, Translation Elongation Factor EEF-1 Gamma Chain, Pancreatic Tumor-Related Protein, PRO1608, GIG35
    Associations

    News

    Trials
    6ms
    BMI-dependent prognostic role of EEF1G in breast cancer: A 15-year follow-up of the Guangzhou Breast Cancer Cohort Study. (PubMed, Cancer Med)
    This study showed EEF1G expression was inversely associated with BC prognosis in different BMI categories, indicating its potential as a prognostic marker and therapeutic target in BC. The differential effects underscore the need for personalized approaches in BC management and research.
    Journal
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    EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma)
    8ms
    Colorectal cancer cell line-derived organoid model with stem cell properties captures the regrowing state of residual cancer cells after neoadjuvant chemotherapy. (PubMed, Cell Death Discov)
    Only the polymerase I-inhibitor BMH-21 significantly reduced tumor growth both in vitro and in vivo, indicating the critical cell subpopulation driving recurrence. Our results demonstrate the possibility of a unique therapeutic target for CRC treatment targeting drug-tolerant residual cancer cells.
    Preclinical • Journal
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    EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma)
    9ms
    Selection and validation of reference genes for quantitative real-time PCR during the developmental stages of seeds in Sophora davidii. (PubMed, Front Plant Sci)
    These findings underscore the necessity of rigorous reference gene validation to ensure reliable gene expression data. The results advance our understanding of quinolizidine alkaloid biosynthesis and highlight the broader importance of reference gene selection in plant molecular studies.
    Journal
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    EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma)
    over1year
    Characterization of metastasis-specific macrophages in colorectal cancer for prognosis prediction and immunometabolic remodeling. (PubMed, Sci Rep)
    The study identifies potential drugs targeting the high-risk group, suggesting therapeutic avenues to improve survival. Conclusively, the EMGS score identifies colorectal cancer patients at high risk of liver metastases, highlighting the role of specific macrophage subsets in tumor progression and providing a basis for personalized treatment strategies.
    Journal • IO biomarker
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    EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma)
    over1year
    Investigation of Common Pathways and Putative Biomarker Candidates of Colorectal Cancer and Insomnia by Using Integrative In-Silico Approaches. (PubMed, Iran J Biotechnol)
    Our in-silico analysis provides promising evidence of the molecular link between CRC and insomnia and highlights multiple potential molecular biomarkers and pathways. Validation of the results by wet lab work can be utilized for novel translational and precision medicine applications to alleviate the public health burden of CRC.
    Journal
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    MIR324 (MicroRNA 324) • RPS6 (Ribosomal Protein S6) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • MIR16 (MicroRNA 16) • MIR769 (MicroRNA 769) • EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
    over2years
    Circulating Tumor DNA (ctDNA) for Plasma Genotyping and Disease Monitoring in ALK-Positive Anaplastic Lymphoma (ALK+ALCL): A Proof of Concept Study (ASH 2023)
    Interestingly, CGP allowed the identification of the ALK:c.3520T>C; p.(Phe1174Leu) mutation in a plasma sample collected during disease progression while the patient was on long lasting crizotinib therapy...Additionally, our unique patient-specific ddPCR approach was proven to be a cost-effective method for MRD monitoring. Altogether, these findings serve as a proof-of-concept for the development of ctDNA techniques in the clinical management of ALK+ALCL.
    Tumor mutational burden • Circulating tumor DNA
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    ALK (Anaplastic lymphoma kinase) • TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • NPM1 (Nucleophosmin 1) • KMT2A (Lysine Methyltransferase 2A) • LRP1B (LDL Receptor Related Protein 1B) • MDM4 (The mouse double minute 4) • EP300 (E1A binding protein p300) • TRAF1 (TNF Receptor Associated Factor 1) • ANKRD26 (Ankyrin Repeat Domain Containing 26) • EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma)
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    TP53 mutation • ALK positive • ALK rearrangement • ALK fusion • NPM1-ALK fusion
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    Xalkori (crizotinib)
    almost3years
    The complexity of EGFR exon 19 deletion and L858R mutant cells as assessed by proteomics, transcriptomics, and metabolomics. (PubMed, Exp Cell Res)
    Because GSH was increased with L858R, we combined osimertinib with the GSH inhibitor buthionine sulfoximine in L858R cells and observed synergistic effects. The complexity of EGFR 19Del and L858R mutant cells was demonstrated by proteomics, transcriptomics, and metabolomics analyses. Therapeutic strategies for lung cancer with different EGFR mutations could be considered because of their different metabolic phenotypes.
    Journal
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    EGFR (Epidermal growth factor receptor) • ENO1 (Enolase 1) • EEF1G (Eukaryotic Translation Elongation Factor 1 Gamma) • LCP1 (Lymphocyte cytosolic protein 1) • PDIA5 (Protein Disulfide Isomerase Family A Member 5)
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    EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR L858R + EGFR exon 19 deletion
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    Tagrisso (osimertinib)