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DRUG:

EDP1503

i
Other names: EDP1503, EDP 1503
Associations
Company:
Evelo Biosci
Drug class:
Microbiome modulator
Associations
4ms
Pembrolizumab and EDP1503 in Advanced Melanoma (clinicaltrials.gov)
P2, N=8, Active, not recruiting, University of Chicago | Suspended --> Active, not recruiting
Enrollment closed • Metastases
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BRAF (B-raf proto-oncogene)
|
Keytruda (pembrolizumab) • EDP1503
10ms
Pembrolizumab and EDP1503 in Advanced Melanoma (clinicaltrials.gov)
P2, N=8, Suspended, University of Chicago | Trial completion date: Nov 2023 --> Nov 2027 | Trial primary completion date: Nov 2023 --> Nov 2027
Trial completion date • Trial primary completion date • Metastases
|
BRAF (B-raf proto-oncogene)
|
Keytruda (pembrolizumab) • EDP1503
over1year
Pembrolizumab and EDP1503 in Advanced Melanoma (clinicaltrials.gov)
P2, N=8, Suspended, University of Chicago | Trial primary completion date: Nov 2022 --> Nov 2023
Trial primary completion date • Metastases
|
BRAF (B-raf proto-oncogene)
|
Keytruda (pembrolizumab) • EDP1503
over3years
Pembrolizumab and EDP1503 in Advanced Melanoma (clinicaltrials.gov)
P2, N=8, Suspended, University of Chicago | N=70 --> 8 | Active, not recruiting --> Suspended | Trial primary completion date: Nov 2021 --> Nov 2022
Enrollment change • Trial suspension • Trial primary completion date
|
BRAF (B-raf proto-oncogene)
|
Keytruda (pembrolizumab) • EDP1503
over4years
[VIRTUAL] Oral delivery of a single microbial strain, EDP1503, induces anti-tumor responses via gut-mediated activation of both innate and adaptive immunity (ESMO-GI 2020)
In a phase I/II clinical trial, the safety, tolerability, and pharmacological effects of orally administered EDP1503 in combination with pembrolizumab are being evaluated in multiple tumor types: microsatellite stable (MSS) metastatic colorectal cancer, triple-negative breast cancer, and a basket of PD-1 relapsed solid tumors. Legal entity responsible for the study The authors. Funding Evelo Biosciences.
PD(L)-1 Biomarker • IO biomarker
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma)
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TILs
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Keytruda (pembrolizumab) • EDP1503