^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    DUSP5 (Dual Specificity Phosphatase 5)

    i
    Other names: DUSP5, Dual Specificity Phosphatase 5, HVH3, Dual Specificity Protein Phosphatase HVH3, Dual Specificity Protein Phosphatase 5, Serine/Threonine Specific Protein Phosphatase, VH1-Like Phosphatase 3, DUSP, VH3
    Associations

    News

    Trials
    26d
    CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer. (PubMed, bioRxiv)
    Notably, Zfp219 ablation synergized with anti-PD-1 blockade in mice to expand effector-like CD8 + T cells, leading to significantly enhanced anti-tumor immunity and tumor clearance in aged hosts. Together, these findings highlight Dusp5 and Zfp219 as critical drivers of age-related T cell dysfunction and as potential therapeutic targets to rejuvenate T cell antitumor immunity in older cancer patients.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • DUSP5 (Dual Specificity Phosphatase 5) • ZNF219 (Zinc finger protein 219)
    26d
    Mesalazine Regulates DUSP1, DUSP4, and DUSP5 Expression in Colorectal Cancer: In Vitro and Bioinformatic Evidence. (PubMed, Pharmaceutics)
    These findings suggest that mesalazine differentially modulates DUSP gene expression in normal and malignant colon epithelial cells, potentially contributing to its antiproliferative and pro-apoptotic effects through the regulation of MAPK signaling. These results provide new insights into the molecular mechanisms underlying the anticancer effects of mesalazine in colorectal cancer.
    Preclinical • Journal
    |
    DLD (Dihydrolipoamide Dehydrogenase) • DUSP1 (Dual Specificity Phosphatase 1) • DUSP4 (Dual Specificity Phosphatase 4) • DUSP5 (Dual Specificity Phosphatase 5)
    1m
    Activated hepatic stellate cell-derived exosomal miR-23a-3p promotes hepatocellular carcinogenesis by regulating DUSP5/ERK signaling. (PubMed, J Adv Res)
    Our results indicate that activated HSCs secrete exosomes enriched with miR-23a-3p, which directly target to inhibit DUSP5, and subsequently activate ERK signaling in hepatocytes, leading to the initiation of cellular malignant transformation and tumorigenesis.
    Journal
    |
    MIR23A (MicroRNA 23a) • DUSP5 (Dual Specificity Phosphatase 5)
    5ms
    Dual-specific phosphatase 5 (DUSP5), upregulated in lung adenocarcinoma, as a potential therapeutic target for lung cancer. (PubMed, Biochem Biophys Res Commun)
    DUSP5 silencing-induced growth suppression was partially due to G1 cell cycle arrest, associated with p21 upregulation. Collectively, our findings highlight DUSP5 as a potential therapeutic target for lung cancer.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • CDK4 (Cyclin-dependent kinase 4) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • DUSP6 (Dual specificity phosphatase 6) • DUSP4 (Dual Specificity Phosphatase 4) • DUSP5 (Dual Specificity Phosphatase 5)
    |
    KRAS mutation • EGFR mutation • BRAF mutation • EGFR expression
    7ms
    Prenatal valproic acid on the basis of gestational diabetes also induces autistic behavior and disrupts myelination and oligodendroglial maturation slightly in offspring. (PubMed, Transl Psychiatry)
    we delineate the antagonistic effects of GDM and prenatal VPA on ERK phosphorylation in fetal OPCs, consequently altering their proliferation and differentiation, thereby culminating in milder dysmyelination and autistic behaviors.
    Journal
    |
    DUSP5 (Dual Specificity Phosphatase 5) • HDAC3 (Histone Deacetylase 3) • LEP (Leptin)
    9ms
    Design and synthesis of 3,4-seco-lupane triterpene-tryptamine derivatives and revealing their anti-bladder cancer mechanisms by combining TCGA and transcriptomic approaches. (PubMed, Sci Rep)
    Molecular docking confirmed the stable binding of compound 27 to DUSP5, which was confirmed by molecular dynamics simulations. Compound 27 inhibited bladder cancer progression by upregulating DUSP5 expression and negatively regulating the p38 MAPK pathway, modulating the immune response and promoting apoptosis.
    Journal
    |
    MEN1 (Menin 1) • DUSP5 (Dual Specificity Phosphatase 5)
    9ms
    Unraveling the genetic blueprint of doxorubicin-induced cardiotoxicity through systems genetics approaches. (PubMed, Cardiooncology)
    Survival, BW loss, and echocardiography parameters considerably varied among DOX-treated BXDs, suggesting significant influence of genetic background on expression of those traits. Several candidate genes that may modulate ACT susceptibility and heart failure were identified, providing a foundation for genetic-based risk stratification and therapeutics in cardio-oncology.
    Journal
    |
    CASP7 (Caspase 7) • DUSP5 (Dual Specificity Phosphatase 5) • PDZD8 (PDZ Domain Containing 8)
    |
    doxorubicin hydrochloride
    10ms
    OTX2 expression contributes progression of gastric cancer in young adults. (PubMed, Sci Rep)
    Therefore, OTX2 plays important roles in restraining the differentiation and promoting progression of gastric cancer cells in young adults. Moreover, OTX2/CEBPB signal axis is likely to be a key molecular event in regulating the differentiation of gastric cancer cells in young adults.
    Journal
    |
    CD73 (5'-Nucleotidase Ecto) • NT5E (5'-Nucleotidase Ecto) • MLLT3 (MLLT3 Super Elongation Complex Subunit) • DFNB31 (Deafness, Autosomal Recessive 31) • TBX1 (T-Box Transcription Factor 1) • ACAN (Aggrecan) • DUSP5 (Dual Specificity Phosphatase 5) • BMP4 (Bone Morphogenetic Protein 4)
    10ms
    Unraveling the Genetic Blueprint of Doxorubicin-Induced Cardiotoxicity Through Systems Genetics Approaches. (PubMed, Res Sq)
    Conclusions Survival, BW loss, and echocardiography parameters considerably varied among DOX-treated BXDs, suggesting significant influence of genetic background on expression of those traits. Several candidate genes that may modulate ACT susceptibility and HF were identified, providing a foundation for genetic-based risk stratification and therapeutics in cardio-oncology.
    Journal
    |
    CASP7 (Caspase 7) • DUSP5 (Dual Specificity Phosphatase 5) • PDZD8 (PDZ Domain Containing 8)
    |
    doxorubicin hydrochloride
    12ms
    Tumor gene expression signatures associated with outcome in large B-cell lymphoma treated with CD19-directed CAR T-cell therapy (axicabtagene ciloleucel). (PubMed, Front Oncol)
    The 6-GES was reduced, whereas the 17-GES was elevated at progression post axi-cel, consistent with the notion that these signatures represent features relevant for response and resistance to CAR T-cell therapy. Our transcriptomic analysis identified gene expression signatures potentially predictive of outcome with CD19-directed CAR T-cell therapy, and these findings are informative for risk stratification and development of next-generation products.
    Journal • IO biomarker
    |
    ER (Estrogen receptor) • BCL2 (B-cell CLL/lymphoma 2) • ARID1A (AT-rich interaction domain 1A) • CD19 (CD19 Molecule) • KIR3DL2 (Killer Cell Immunoglobulin Like Receptor Three Ig Domains And Long Cytoplasmic Tail 2) • NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)) • CCL2 (Chemokine (C-C motif) ligand 2) • RPS6KB1 (Ribosomal Protein S6 Kinase B1) • SLC16A1 (Solute Carrier Family 16 Member 1) • CCL22 (C-C Motif Chemokine Ligand 22) • SOX11 (SRY-Box Transcription Factor 11) • TNFSF4 (TNF Superfamily Member 4) • DUSP5 (Dual Specificity Phosphatase 5) • KLRB1 (Killer Cell Lectin Like Receptor B1) • NKG2D (killer cell lectin like receptor K1) • SERPINA9 (Serpin Family A Member 9) • SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5)
    |
    Yescarta (axicabtagene ciloleucel)
    over1year
    Glabridin inhibits proliferation and migration in hepatocellular carcinoma by regulating multi-targets. (PubMed, J Ethnopharmacol)
    Gla regulates the expression levels of DUSP5, ZFP36, KLF10, NR4A1, and RMI2 to against HCC, providing valuable insights for the application of Gla in HCC treatment.
    Journal
    |
    NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) • DUSP5 (Dual Specificity Phosphatase 5) • KLF10 (Kruppel Like Factor 10) • ZFP36 (ZFP36 Ring Finger Protein)
    over1year
    Corynoxine exerts the anti-tumor effect on esophageal squamous cell carcinoma principally via the EZH2-DUSP5-ERK1/2-mediated cell growth inhibition. (PubMed, Phytomedicine)
    Cory plays an anti-tumor role in ESCC by regulating EZH2-DUSP5-ERK1/2 signaling pathway. Cory may be promising to be a novel therapy for treating ESCC.
    Journal
    |
    EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • DUSP5 (Dual Specificity Phosphatase 5)