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GENE:

DUSP1 (Dual Specificity Phosphatase 1)

News alerts, weekly reports and conference planners

10d

LDHB Deficiency in Fibroblasts Induces Lactate-Mediated Inflammatory Reprogramming that Promotes Breast Cancer Metastasis. (PubMed, Cancer Res)

Persistent p38 signaling reprogrammed CAFs into an inflammatory phenotype characterized by abundant secretion of the chemokine CXCL8, which in turn enhanced metastasis of breast cancer cells. In summary, these findings identify LDHB as a key metabolic regulator in CAFs and provide insights into how metabolic reprogramming promotes the inflammatory, pro-metastatic phenotype of CAFs, highlighting activating LDHB as a potential strategy for limiting cancer metastasis.

10 days ago

Journal

LDHB (L-lactate dehydrogenase B chain) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • DUSP1 (Dual Specificity Phosphatase 1)

12d

Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy. (PubMed, Cell Death Dis)

In summary, paclitaxel induces transcriptomic and proteomic signatures of the neuronal stress response, neuroinflammation, nociception, and disturbed metabolism. These may explain, in part, the clinical phenotype of sensory loss, hypersensitivity, and neuropathic pain frequently observed in patients suffering from CIPN, but constitute pharmacologically addressable targets.

12 days ago

Journal

CD123 (Interleukin 3 Receptor Subunit Alpha) • BCL2L11 (BCL2 Like 11) • CASP3 (Caspase 3) • CYSLTR2 (Cysteinyl Leukotriene Receptor 2) • IL1R1 (Interleukin 1 receptor, type I) • ARID5A (AT-Rich Interaction Domain 5A) • ATF3 (Activating Transcription Factor 3) • BBC3 (BCL2 Binding Component 3) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) • DUSP1 (Dual Specificity Phosphatase 1) • HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1) • TNFRSF12A (TNF Receptor Superfamily Member 12A)

paclitaxel

26d

Mesalazine Regulates DUSP1, DUSP4, and DUSP5 Expression in Colorectal Cancer: In Vitro and Bioinformatic Evidence. (PubMed, Pharmaceutics)

These findings suggest that mesalazine differentially modulates DUSP gene expression in normal and malignant colon epithelial cells, potentially contributing to its antiproliferative and pro-apoptotic effects through the regulation of MAPK signaling. These results provide new insights into the molecular mechanisms underlying the anticancer effects of mesalazine in colorectal cancer.

26 days ago

Preclinical • Journal

DLD (Dihydrolipoamide Dehydrogenase) • DUSP1 (Dual Specificity Phosphatase 1) • DUSP4 (Dual Specificity Phosphatase 4) • DUSP5 (Dual Specificity Phosphatase 5)

A Meta-Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data. (PubMed, Brain Behav)

Our study demonstrates that chronic stress induces a robust, cross-paradigm PFC signature characterized by downregulation of glia/myelin and vascular pathways and suppression of immediate-early gene activity, highlighting cellular processes linking chronic stress exposure, PFC dysfunction, and psychiatric disorders.

1 month ago

Clinical • Preclinical • Retrospective data • Review • Journal

DUSP1 (Dual Specificity Phosphatase 1) • JUNB (JunB Proto-Oncogene AP-1 Transcription Factor Subunit)

2ms

Integrated transcriptomic analysis reveals a CEBPB-DUSP1 axis driving tumor progression in colorectal cancer. (PubMed, PLoS One)

Overall, this work highlights CEBPB as a potential biomarker for poor prognosis and points to the CEBPB-DUSP1 axis as a promising therapeutic target. Our findings also demonstrate the power of integrated transcriptomic approaches in elucidating intricate gene regulatory networks, offering a basis for new strategies to mitigate CRC progression.

2 months ago

Journal

DUSP1 (Dual Specificity Phosphatase 1)

3ms

MT1H Inhibited Colon Cancer Development via Interacting With DUSP1 and MAPK Signaling Pathway Inactivation. (PubMed, J Biochem Mol Toxicol)

Taken together, these results suggest MT1H expression hinders CC progression by interacting with DUSP1 and subsequently deactivating the MAPK signaling. MT1H might be a novel target in CC treatment.

3 months ago

Journal

DUSP1 (Dual Specificity Phosphatase 1) • MAPK8 (Mitogen-activated protein kinase 8)

3ms

Gypenoside LI Inhibits Renal Cancer Proliferation by Affecting Lipid Metabolism through the Upregulation of Dual-Specificity Phosphatase 1. (PubMed, Comb Chem High Throughput Screen)

Gyp LI upregulates DUSP1 to suppress the metabolism of choline, linoleic acid, and alpha-linolenic acid, ultimately suppressing the incidence and progression of ccRCC.

3 months ago

Journal

DUSP1 (Dual Specificity Phosphatase 1)

3ms

Regulatory roles of MKP7/DUSP16 in cancer. (PubMed, Med Oncol)

This review summarizes the mechanisms by which MKP7/DUSP16 may promote tumor proliferation. Further studies are needed to clarify its specific regulatory roles in cancer.

3 months ago

Review • Journal

DUSP1 (Dual Specificity Phosphatase 1)

3ms

Network modeling and analysis of MAP Kinase pathway to assess role of genes in tumor development. (PubMed, Phys Biol)

Thus highlighting its potential in designing novel therapeutic interventions. Moreover, though MYC is a well-known oncogene we found that MYC's overexpression can activate p53, a prominent anti-growth agent, through p14 and MDM2 pathway. Implications: Our findings suggest a novel role of DUSP1 and MYC gene in regulating cell proliferation. .

3 months ago

Journal

TP53 (Tumor protein P53) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • TNFA (Tumor Necrosis Factor-Alpha) • FASLG (Fas ligand) • DUSP1 (Dual Specificity Phosphatase 1)

3ms

Exploratory Analysis of the Impact of a Single Dose of Trastuzumab on the Immune Microenvironment in HER2-Positive Early-Stage Breast Cancer. (PubMed, Biomedicines)

These findings, although exploratory in nature, highlight trastuzumab's ability to induce an immune response and suggest that some patients may be more primed to mount an immune response following treatment than others. Patients without a robust response in TILs may benefit from additional agents to favorably modulate the TME for optimized responses to HER2-directed therapy, an area of research which warrants further study.

3 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • TGFB1 (Transforming Growth Factor Beta 1) • DUSP1 (Dual Specificity Phosphatase 1)

HER-2 positive

Herceptin (trastuzumab)

3ms

A Meta-Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence with Existing Human Data. (PubMed, bioRxiv)

In these studies, mice that had experienced chronic stress showed a decreased amount of mRNA related to a variety of non-neuronal support cells (glia) and blood vessels, and general neural activity. The mouse chronic stress signature overlapped with gene-activity patterns reported in human psychiatric conditions, suggesting a biological bridge between chronic stress and the onset of psychopathology.

3 months ago

Preclinical • Retrospective data • Journal

DUSP1 (Dual Specificity Phosphatase 1) • JUNB (JunB Proto-Oncogene AP-1 Transcription Factor Subunit)

3ms

Expression Profiles of Ferroptosis-Related Genes and Their Diagnostic Value in Infants with Bronchopulmonary Dysplasia. (PubMed, Pediatr Allergy Immunol Pulmonol)

The results in this study shed more insights on the diagnosis and mechanism of ferroptosis in BPD. Further research should be carried out to assess its clinical utility.

3 months ago

Journal • IO biomarker

TP53 (Tumor protein P53) • STAT3 (Signal Transducer And Activator Of Transcription 3) • TLR4 (Toll Like Receptor 4) • DUSP1 (Dual Specificity Phosphatase 1) • MAPK14 (Mitogen-Activated Protein Kinase 14)