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    DRUG CLASS:

    DRD3 antagonist

    Related drugs:
    3d
    Dexmedetomidine versus Chlorpromazine for Patients in ICU with Hyperactive Delirium: A Single-Center, Prospective, Double-Blind, Randomized Controlled Trial (ChiCTR2500114067)
    P=N/A, N=104, Not yet recruiting, Huashan Hospital Fudan University; Huashan Hospital Fudan University
    New trial
    |
    chlorpromazine
    6d
    NOVA3: 52-week Open Label Safety-Tolerability Study (clinicaltrials.gov)
    P3, N=900, Not yet recruiting, LB Pharmaceuticals Inc.
    New P3 trial
    11d
    NOVA2: Study to Evaluate LB-102 for the Treatment of Adult Patients With Acute Schizophrenia (clinicaltrials.gov)
    P3, N=456, Not yet recruiting, LB Pharmaceuticals Inc.
    New P3 trial
    17d
    Characterizing Drug Liking During Drug Administration in Peri-procedural Clinical Settings (clinicaltrials.gov)
    P1, N=100, Not yet recruiting, Stanford University
    New P1 trial
    1m
    ENX-104 MAD Study for Participants With Major Depressive Disorder With Anhedonia (aMDD) (clinicaltrials.gov)
    P1, N=48, Completed, Engrail Therapeutics INC | Recruiting --> Completed
    Trial completion
    2ms
    A PET Study of ENX-104 in Healthy Volunteers (clinicaltrials.gov)
    P1, N=10, Completed, Engrail Therapeutics INC
    New P1 trial
    2ms
    ENX-104 MAD Study for Participants With Major Depressive Disorder With Anhedonia (aMDD) (clinicaltrials.gov)
    P1, N=42, Recruiting, Engrail Therapeutics INC
    New P1 trial
    2ms
    Drug Repurposing Screen Identifies Pimozide as a ROS-Inducing Therapy With Anti-Tumor Efficacy in HNSCC PDX Models. (PubMed, Cancer Sci)
    Notably, pimozide exhibited anti-tumor effects as a monotherapy and in combination with paclitaxel at clinically relevant doses. While tumor volume reduction in the combination group was not statistically greater than that in the monotherapy group, fluorescence immunohistochemistry revealed a marked decrease in undifferentiated tumor cells, indicating enhanced therapeutic effects of combination treatment. Taken together, these findings indicate that pimozide is a promising candidate for repurposing as a novel therapeutic agent against HNSCC.
    Journal
    |
    STAT3 (Signal Transducer And Activator Of Transcription 3) • DRD2 (Dopamine Receptor D2) • EGR1 (Early Growth Response 1)
    |
    paclitaxel
    3ms
    Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy (clinicaltrials.gov)
    P2/3, N=42, Recruiting, M.D. Anderson Cancer Center | N=30 --> 42
    Enrollment change
    |
    chlorpromazine
    3ms
    Role of Ubiquitin-specific Protease 1 in the Pathogenesis and Treatment of Adult T-Cell Leukemia. (PubMed, Anticancer Res)
    Our study supports the clinical potential of USP1 inhibitors as a novel therapy for ATL.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • LDHA (Lactate dehydrogenase A) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • PLK1 (Polo Like Kinase 1) • USP1 (Ubiquitin Specific Peptidase 1)
    3ms
    Antipsychotic Chlorpromazine Suppresses STAT5 Signaling, Overcomes Resistance Mediated by the Gatekeeper Mutation FLT3-ITD/F691L, and Synergizes with Quizartinib in FLT3-ITD-Positive Cells. (PubMed, Curr Issues Mol Biol)
    Although FLT3 tyrosine kinase inhibitors (TKIs), such as quizartinib (Quiz) and gilteritinib, have improved clinical outcomes, secondary TKD mutations, particularly the gatekeeper mutation F691L, confer significant resistance. Expression of constitutively active STAT5 partially rescued CPZ-induced growth inhibition. These findings suggest that STAT5 suppression is a key mechanism of CPZ's antileukemic activity and support its potential as a therapeutic strategy for FLT3-ITD-positive AML.
    Journal
    |
    FLT3 (Fms-related tyrosine kinase 3) • STAT5A (Signal Transducer And Activator Of Transcription 5A)
    |
    FLT3-ITD mutation • FLT3 mutation
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    Xospata (gilteritinib) • Vanflyta (quizartinib) • chlorpromazine
    3ms
    Bridging clinical insight and laboratory model in high-grade serous ovarian carcinoma (HGSOC) using DNA sequencing-based profiling of TP53. (PubMed, Oncoscience)
    In this study, drug repurposing agent's metformin, chlorpromazine (CPZ) alone and combine were tested on both clinical and laboratory ovarian cancer samples to evaluate on hemocytometer and clonogenic assay for dead cell and proliferation respectively. The resulting data were analyzed to achieve successfully known target region and worked as a bridge between clinical and laboratory model. The insights gained from this study not only validate OVCAR3 as a representative model for HGSOC but also provide a foundation for developing targeted therapeutic strategies.
    Journal
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    TP53 (Tumor protein P53)
    |
    TP53 wild-type
    |
    metformin • chlorpromazine