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    BIOMARKER:

    DOCK8 mutation

    i
    Other names: DOCK8, Dedicator Of Cytokinesis 8, ZIR8, Dedicator Of Cytokinesis Protein 8, FLJ00026, FLJ00152, FLJ00346, Epididymis Luminal Protein 205, 1200017A24Rik, HEL-205, MRD2
    Entrez ID:
    81704
    11d
    Clinical and molecular profile of 20 patients with DOCK8 deficiency-a single-center experience from Southern India. (PubMed, Immunol Res)
    We present one of the largest single-center experiences on DOCK8 deficiency from India. A significant delay in the diagnosis contributed to poor outcomes in our cohort.
    Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • DOCK8 (Dedicator Of Cytokinesis 8)
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    DOCK8 mutation
    1year
    A systematic review regarding the prevalence of malignancy in patients with the hyper-IgE syndrome. (PubMed, Clin Exp Med)
    The results of this study indicated that in 6.5% of cases, HIES was complicated with malignancy, and considering the higher rate of these malignancies in women as well as in DOCK8 mutation sufferers, it is necessary for physicians to be aware of this association and includes malignancy screening in follow-up and periodic examinations of these patients. Indeed, more studies in this field will help to clarify the precise figures and predisposing factors of the relationship between HIES and malignancy.
    Review • Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • TYK2 (Tyrosine Kinase 2) • DOCK8 (Dedicator Of Cytokinesis 8)
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    STAT3 mutation • DOCK8 mutation