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    BIOMARKER:

    DNMT3A mutation + NRAS mutation

    i
    Other names: NRAS1, N-Ras Protein Part 4, Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog, NRAS, Neuroblastoma RAS Viral Oncogene Homolog, NRAS Proto-Oncogene, GTPase, DNMT3A, DNA Methyltransferase 3 Alpha, DNA (Cytosine-5-)-Methyltransferase 3 Alpha, DNA (Cytosine-5)-Methyltransferase 3A, DNA MTase HsaIIIA, DNA Cytosine Methyltransferase 3A2, DNA Methyltransferase HsaIIIA, DNMT3A2, Dnmt3a
    Entrez ID:
    4893; 1788
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    over1year
    Correlation Analysis and Prognostic Impacts of Biological Characteristics in Elderly Patients with Acute Myeloid Leukemia. (PubMed, Clin Interv Aging)
    ASXL1+/CD38+ and SRSF2+/CD123- predicted shorter OS. The study showed specific correlations between elderly AML patients' genetic mutations and clinical features, some of which may impact prognosis.
    Journal • IO biomarker
    |
    TP53 (Tumor protein P53) • FLT3 (Fms-related tyrosine kinase 3) • NRAS (Neuroblastoma RAS viral oncogene homolog) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • NPM1 (Nucleophosmin 1) • DNMT3A (DNA methyltransferase 1) • RUNX1 (RUNX Family Transcription Factor 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • CD38 (CD38 Molecule) • SRSF2 (Serine and arginine rich splicing factor 2) • WT1 (WT1 Transcription Factor) • BCOR (BCL6 Corepressor) • CD123 (Interleukin 3 Receptor Subunit Alpha) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1) • CD34 (CD34 molecule) • ITGAM (Integrin, alpha M) • BCORL1 (BCL6 Corepressor Like 1)
    |
    TP53 mutation • NRAS mutation • FLT3-ITD mutation • DNMT3A mutation • TET2 mutation • SRSF2 mutation • U2AF1 mutation • WT1 mutation • NPM1 expression • DNMT3A mutation + NRAS mutation