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    BIOMARKER:

    DNMT1 rs2228611

    i
    Other names: DNMT1, DNA methyltransferase 1, DNA (Cytosine-5-)-Methyltransferase 1, CXXC-Type Zinc Finger Protein 9, DNA Methyltransferase HsaI, DNA MTase HsaI, M.HsaI, CXXC9, DNMT, MCMT, ADCADN, HSN1E, Dnmt1
    Entrez ID:
    1786
    Related biomarkers:
    Expression
    Mutation
    22d
    DNMT1 rs2228611, rs2228612 and DNMT3A rs2276598, rs752208 Polymorphisms and Their Association with Breast Cancer Phenotype and Prognosis. (PubMed, Medicina (Kaunas))
    The DNMT1 rs2228611 G allele may be associated with earlier onset, and the DNMT3A rs752208 T allele might correlate with less aggressive tumors. These findings underscore the potential of DNMT gene polymorphisms as prognostic biomarkers in breast cancer, warranting further investigation with larger sample sizes.
    Journal
    |
    DNMT3A (DNA methyltransferase 1) • DNMT1 (DNA methyltransferase 1)
    |
    DNMT1 rs2228611
    9ms
    Association study of the polymorphisms rs2228611 of the DNMT1 gene and rs1569686 of the DNMT3B gene with bladder cancer development in a sample of the Algerian population. (PubMed, Mol Biol Res Commun)
    Our results suggest that the rs2228611 might be a potential biomarker for BC development risk. Additional studies are needed to validate our findings.
    Journal
    |
    DNMT1 (DNA methyltransferase 1) • DNMT3B (DNA Methyltransferase 3 Beta)
    |
    DNMT1 rs2228611
    over1year
    DNA Methyltransferase Genes Are Associated with Oral Mucositis and Creatinine Levels in Oncopediatric Patients. (PubMed, Genes (Basel))
    The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) and the DNA methylation profiles of the DNA methyltransferase (DNMT) gene family with oral mucositis in children and adolescents with hematologic malignancies treated with methotrexate (MTX)...In addition, the DNMT3B unmethylated profile associated with the CC genotype (SNP rs6087990) appeared to be connected with higher values of creatinine. We conclude that the DNMT1 methylation profile is associated with the post-mucositis period and that the genetic and epigenetic profiles of DNMT3A and DNMT3B are associated with creatinine levels.
    Journal • Epigenetic controller
    |
    DNMT3A (DNA methyltransferase 1) • DNMT1 (DNA methyltransferase 1) • DNMT3B (DNA Methyltransferase 3 Beta)
    |
    DNMT1 rs2228611
    |
    methotrexate
    almost3years
    Association Between SNPs in the One-Carbon Metabolism Pathway and the Risk of Female Breast Cancer in a Chinese Population. (PubMed, Pharmgenomics Pers Med)
    In addition, stratified analysis revealed that DNMT1 rs16999593, rs2228611 and ALDH1L1 rs2002287 contributed to the risk of BC, with associations with ER, PR and HER-2 expression. In summary, this study revealed that DNMT1 rs16999593 and rs2228611 were associated with BC risk.
    Clinical • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • MTHFR (Methylenetetrahydrofolate Reductase) • DNMT1 (DNA methyltransferase 1) • DNMT3B (DNA Methyltransferase 3 Beta)
    |
    HER-2 expression • ER expression • PGR expression • DNMT1 rs2228611