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    GENE:

    DNAJB8 (DnaJ Heat Shock Protein Family (Hsp40) Member B8)

    i
    Other names: DNAJB8, DnaJ Heat Shock Protein Family (Hsp40) Member B8, CT156, DnaJ (Hsp40) Homolog, Subfamily B, Member 8, DnaJ Homolog Subfamily B Member 8, MGC33884, Testicular Tissue Protein Li 56, DJ6
    Associations

    News

    Trials
    almost3years
    Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours. (PubMed, Br J Cancer)
    B10 CAR-T cells could show specific cytotoxicity against RCC and osteosarcoma cells in vitro and in vivo. B10 CAR-T cells targeting the CSC/CIC antigen DNAJB8 might be a candidate immunotherapy for carcinoma and sarcoma.
    Journal • CAR T-Cell Therapy • Cancer stem
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    DNAJB8 (DnaJ Heat Shock Protein Family (Hsp40) Member B8)
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    HLA-A*24:02
    almost4years
    DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer. (PubMed, Cell Death Dis)
    These results indicate that DNAJB8 levels in serum sEVs may serve as a biomarker for COAD. DNAJB8 from sEVs might be a promising therapeutic target for L-OHP resistance and a prognostic predictor of clinical response.
    Journal
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    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) • DNAJB8 (DnaJ Heat Shock Protein Family (Hsp40) Member B8)
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    oxaliplatin