DNAH8 (Dynein Axonemal Heavy Chain 8)

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7ms

Somatic Mutations Profiling in Genes Other than BRCA and TP53 Increasing Breast Carcinoma Risk Among Pakistani Patients. (PubMed, Rev Recent Clin Trials)

This study unveils new somatic alterations in different genes among early-onset Pakistani breast cancer patients, offering valuable insights for drug design targeting breast carcinoma.

7 months ago

Journal • BRCA Biomarker

EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • RB1 (RB Transcriptional Corepressor 1) • ARID1A (AT-rich interaction domain 1A) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • KMT2C (Lysine Methyltransferase 2C) • BRCA (Breast cancer early onset) • CDH1 (Cadherin 1) • MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1) • GATA3 (GATA binding protein 3) • DNAH8 (Dynein Axonemal Heavy Chain 8) • LAMA3 (Laminin Subunit Alpha 3) • TNN (Tenascin N) • CDC27 (Cell Division Cycle 27)

TP53 mutation • BRCA mutation

10ms

Beyond environmental risk: Genetic insights into lung cancer susceptibility through whole exome analysis. (PubMed, Lung Cancer)

several lines of evidence suggest that these genes are of potential clinical impact in lung cancer even though they have not been correlated with lung cancer in the OMIM database or other genetic databases. Therefore, these genes deserve further investigations: segregation analysis, enlarged cohorts and in vitro/in vivo studies could help to clarify their role in lung cancer.

10 months ago

Journal

EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • GLI3 (GLI Family Zinc Finger 3) • MITF (Melanocyte Inducing Transcription Factor) • DNAH8 (Dynein Axonemal Heavy Chain 8) • HNF1A (HNF1 Homeobox A) • NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4) • SERPINA3 (Serpin Family A Member 3) • TNFAIP8 (TNF Alpha Induced Protein 8) • CASP1 (Caspase 1) • VIRMA (Vir Like M6A Methyltransferase Associated)

almost2years

Prognostic factors of 87 ovarian yolk sac tumor (OYST) patients and molecular characteristics of persistent and recurrent OYST. (PubMed, Gynecol Oncol)

Persistent and recurrent OYST associated with poor prognosis, and probably susceptible to immune checkpoint blockade therapy. Molecular characteristics contributed to predict the persistence and recurrence of OYST.

almost 2 years ago

Journal

PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • ARID1A (AT-rich interaction domain 1A) • MUC16 (Mucin 16, Cell Surface Associated) • MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) • DNAH8 (Dynein Axonemal Heavy Chain 8) • NUP205 (Nucleoporin 205)

PIK3CA mutation • ARID1A mutation

almost3years

A lipid metabolism-based prognostic risk model for HBV-related hepatocellular carcinoma. (PubMed, Lipids Health Dis)

This study established a robust model to stratify HBV-related HCC effectively. Analysis results decode in part the heterogeneity of HBV-related liver cancer and highlight perturbation of lipid metabolism in HBV-related HCC. This study's findings could facilitate patients' clinical classification and give hints for treatment selection.

almost 3 years ago

Journal

TP53 (Tumor protein P53) • CD8 (cluster of differentiation 8) • LRP1B (LDL Receptor Related Protein 1B) • TTN (Titin) • BTLA (B And T Lymphocyte Associated) • DNAH8 (Dynein Axonemal Heavy Chain 8)

3years

Comparative genomic analysis of esophageal squamous cell carcinoma among different geographic regions. (PubMed, Front Oncol)

Our study provides insights into genomic differences in ESCC among different regions. These differences may be related to differences in environmental carcinogens, incidence, and survival.

3 years ago

Journal • Tumor mutational burden

TMB (Tumor Mutational Burden) • NOTCH1 (Notch 1) • KMT2D (Lysine Methyltransferase 2D) • FAT1 (FAT atypical cadherin 1) • DNAH8 (Dynein Axonemal Heavy Chain 8)