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    DRUG CLASS:

    DNA polymerase inhibitor

    Related drugs:
    1d
    CPX-351 Selectively Benefits Patients with AML and Myelodysplasia-Related Mutations in the Pivotal Randomized Trial. (PubMed, Blood Adv)
    The OS benefit of CPX-351 observed in the trial was driven by AML-MR with no benefit of CPX-351 in TP53-AML, where the primary prognostic factor was allelic state. Clinical Trial Information: NCT01696084.
    Journal
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    TP53 (Tumor protein P53) • DDX41 (DEAD-Box Helicase 41)
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    TP53 mutation
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    Vyxeos (cytarabine/daunorubicin liposomal formulation)
    3d
    A Randomized Controlled Clinical Study on Transfer Factor Oral Solution in the Treatment of Herpes Zoster (ChiCTR2600117507)
    P4, N=90, Recruiting, Dermatology Hospital, Southern Medical University; Dermatology Hospital, Southern Medical University
    New P4 trial
    11d
    Oral Herpesviruses and Oral Mucositis in Patients Receiving Head and Neck Radiotherapy (clinicaltrials.gov)
    P2, N=84, Enrolling by invitation, Instituto Oncoclinicas
    New P2 trial
    14d
    Ultrasound-Guided Thoracic Paravertebral Block With Steroid and Local Anesthetic for Acute Herpes Zoster: Effects on Pain Control and Prevention of Postherpetic Neuralgia (clinicaltrials.gov)
    P3, N=100, Completed, Assiut University
    New P3 trial
    2ms
    Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome (clinicaltrials.gov)
    P1/2, N=52, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Dec 2025 --> Dec 2027 | Trial primary completion date: Dec 2025 --> Dec 2027
    Trial completion date • Trial primary completion date
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    Vanflyta (quizartinib) • Vyxeos (cytarabine/daunorubicin liposomal formulation)
    2ms
    NCI-2019-08946: CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old (clinicaltrials.gov)
    P2, N=21, Active, not recruiting, Roswell Park Cancer Institute | Suspended --> Active, not recruiting | N=46 --> 21 | Trial primary completion date: Jan 2027 --> Jun 2025
    Enrollment closed • Enrollment change • Trial primary completion date
    |
    Vyxeos (cytarabine/daunorubicin liposomal formulation)
    2ms
    MCC-21450: CPX-351 in Combination With Gemtuzumab Ozogamicin in Newly Diagnosed AML (clinicaltrials.gov)
    P1, N=18, Recruiting, H. Lee Moffitt Cancer Center and Research Institute | Trial completion date: Nov 2025 --> Apr 2027 | Trial primary completion date: Nov 2025 --> Apr 2027
    Trial completion date • Trial primary completion date
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    CD33 (CD33 Molecule)
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    Mylotarg (gemtuzumab ozogamicin) • Vyxeos (cytarabine/daunorubicin liposomal formulation)
    2ms
    CPX-351 and the Frontier of Nanoparticle-Based Therapeutics in Acute Myeloid Leukemia. (PubMed, Int J Mol Sci)
    Despite these gains, the absolute survival benefit remains modest, prolonged cytopenias are universal, and outcomes in TP53-mutated or younger adverse-risk patients are still poor, raising legitimate questions about cost-effectiveness and generalizability. Nonetheless, CPX-351 stands as the first clinically validated example of ratiometric nanomedicine in oncology, proving that reformulating established drugs can yield meaningful progress where novel agents have often failed.
    Review • Journal
    |
    TP53 (Tumor protein P53)
    |
    TP53 mutation
    |
    Vyxeos (cytarabine/daunorubicin liposomal formulation)
    2ms
    AAML1831: A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations (clinicaltrials.gov)
    P3, N=1186, Recruiting, Children's Oncology Group | Trial completion date: Sep 2027 --> Jun 2029 | Trial primary completion date: Sep 2027 --> Jun 2029
    Trial completion date • Trial primary completion date
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    FLT3 (Fms-related tyrosine kinase 3)
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    Xospata (gilteritinib) • etoposide IV • methotrexate • Mylotarg (gemtuzumab ozogamicin) • Vyxeos (cytarabine/daunorubicin liposomal formulation) • mitoxantrone • Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn) • Starasid (cytarabine ocfosfate) • dexrazoxane
    2ms
    VYSION: VYxeoS Liposomal Italian Observational Study iN the Real Practice (clinicaltrials.gov)
    P=N/A, N=113, Completed, Jazz Pharmaceuticals | Active, not recruiting --> Completed | Trial completion date: Feb 2026 --> Oct 2025 | Trial primary completion date: Feb 2026 --> Oct 2025
    Trial completion • Trial completion date • Trial primary completion date
    |
    Vyxeos (cytarabine/daunorubicin liposomal formulation)
    3ms
    NCI-2019-08946: CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old (clinicaltrials.gov)
    P2, N=46, Suspended, Roswell Park Cancer Institute | Recruiting --> Suspended
    Trial suspension
    |
    Vyxeos (cytarabine/daunorubicin liposomal formulation)