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    BIOMARKER:

    DKK3 overexpression

    i
    Other names: Dickkopf WNT Signaling Pathway Inhibitor 3, REIC, Dickkopf-Related Protein 3, Regulated In Glioma, Dickkopf-3, HDkk-3, Dkk-3, RIG, Dickkopf (Xenopus Laevis) Homolog 3, Dickkopf 3 Homolog (Xenopus Laevis), Dickkopf 3 Homolog, Dickkopf Homolog 3, RIG-Like 5-6, RIG-Like 7-1, DKK3
    Entrez ID:
    27122
    9ms
    ICBP90, an epigenetic regulator, induces DKK3 promoter methylation, promotes glioma progression, and reduces sensitivity to cis-platinum. (PubMed, Exp Cell Res)
    Besides, DKK3 over-expression restored the effects of ICBP90 over-expression on cell proliferation, migration, invasion and DDP sensitivity. Our findings suggest that ICBP90 inhibits the expression of DKK3 in glioma by maintaining DKK3 promoter methylation, thereby conducing to ICBP90-mediated carcinogenesis and drug insensitivity.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3) • UHRF1 (Ubiquitin Like With PHD And Ring Finger Domains 1) • CASP1 (Caspase 1)
    |
    MYC expression • CCND1 expression • DKK3 overexpression
    1year
    DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database. (PubMed, J Oral Biosci)
    These results suggested the cancer-promoting ability of DKK3, the expression of which is a promising prognostic marker and therapeutic target for HNSCC.
    Journal
    |
    PDGFRB (Platelet Derived Growth Factor Receptor Beta) • DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3) • COL8A1 (Collagen Type VIII Alpha 1 Chain) • P4HA3 (Prolyl 4-Hydroxylase Subunit Alpha 3)
    |
    DKK3 overexpression
    over1year
    DKK3's protective role in prostate cancer is partly due to the modulation of immune-related pathways. (PubMed, Front Immunol)
    On the other hand, both IRAK1 and RIOK1 were downregulated and involved in tumor initiation, tumor progression, poor outcome, and radiotherapy resistance. Together, our results highlighted the possible role of the DKK3-related genes in protecting against PCa initiation and progression.
    Journal
    |
    IL32 (Interleukin 32) • DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3) • IRAK1 (Interleukin 1 Receptor Associated Kinase 1)
    |
    DKK3 overexpression
    over2years
    Apogossypolone Inhibits Cell Proliferation and Epithelial-Mesenchymal Transition in Cervical Cancer via Activating DKK3. (PubMed, Front Oncol)
    In addition, ApoG2 treatment inhibited CC xenograft tumor growth and upregulated the protein levels of DKK3, cleaved caspase-3 and E-cadherin. In conclusions, these findings suggested that ApoG2 could effectively inhibit the growth and invasion of CC cells at least partly by activating DKK3.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • CASP3 (Caspase 3) • VIM (Vimentin) • CDH2 (Cadherin 2) • DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3)
    |
    DKK3 overexpression
    |
    R-(-)-gossypol (AT 101)