DKK1 (dickkopf WNT signaling pathway inhibitor 1)

In xenograft models of human myeloma, pancreatic, lung, and breast cancers and patient-derived xenograft of pancreatic cancer, DKK1-A2 but not CD19 CAR-T cells effectively control or eradicate established tumors without detectable toxicities in NSG or human DKK1 and HLA-A2-trangenic mice. This study indicates that DKK1-A2 CAR-T cells may be used to treat human cancers.

CLDN18.2, as an emerging target, has been proven in multiple studies to have potential in the treatment of advanced gastric cancer, with drugs targeting CLDN18.2, such as Zolbetuximab, already approved, opening new pathways for precision treatment. Furthermore, research on targets such as FGFR2b, MET, DKK1, and TROP2 continues, aiming to offer personalized treatment plans for patients with different biomarker profiles. Although the current biomarkers have certain limitations in treatment, the continuous discovery of new targets and the deepening of clinical research hold great promise for precision treatment of gastric cancer and are expected to significantly improve the prognosis of advanced gastric cancer patients.

P=N/A, N=120, Not yet recruiting, Hebei General Hospital; Hebei General Hospital

Results showed that DHA exhibits multiple biological activities: DHA exhibits anti-aging activity by promoting collagen I synthesis in HDF cell, exhibits anti-hair loss effect by modulating VEGF and DKK1 expression in DPC cell, exhibits antibacterial activity against Malassezia furfur, exhibits whitening activity by suppressing melanin synthesis, and exhibits anti-glycation activity by suppressing glycation reactions. Overall, with the broad biological activities, we believe that DHA holds encouraging promise in the cosmetics industry.

This study underscores the dual role of CSF1 in regulating both tumor survival and M2 macrophage activation in HNSCC. Targeting the DKK1/CSF1 axis may represent a promising strategy to overcome chemoresistance by disrupting tumor-macrophage crosstalk and reprogramming the immunosuppressive microenvironment.

Emerging induced pluripotent stem cell-derived bone marrow organoids (iBMOs) offer a fully human platform capable of modeling both osteoclast and osteoblast dynamics. While current iBMOs lack mineralized bone and mature vascular or immune components, advances in differentiation control and matrix engineering are expected to bridge these gaps, providing physiologically relevant and ethically sustainable models for studying MBD and testing therapeutic interventions.

Sequencing anti-PD1 followed by cisplatin improved intracranial cisplatin delivery and therapeutic efficacy in ICI-resistant BrM. These findings identify anti-PD1-induced BBB modulation as a tractable vulnerability in BrM management.

Our computation analysis showed that ETZ strongly bind with key regulatory genes thereby altering their expressions. These findings suggest that ETZ is a potent reno-toxic agent at low, moderate, and high dose administration.

Acute whey protein supplementation did not induce a different bone or inflammatory response following exhaustive running exercise in young endurance runners compared to the control.

Conclusion While DKK1, HOXC6, and YKT6 did not demonstrate significant differential expression, the study highlights strong associations between OSCC and lifestyle-related risk factors. As the first gene expression study on OSCC in Central India, it underscores the need for larger, tissue-based studies to validate these findings and explore molecular targets for early diagnosis and immunotherapy.

Although the observed effects of GY on the assessed biomarkers were limited and should be interpreted cautiously due to pilot design and statistical constraints, they highlight the need for longer interventions to determine whether whole-food dairy proteins can meaningfully support skeletal and immune health in older adults.