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    GENE:

    DIABLO (Diablo IAP-Binding Mitochondrial Protein)

    i
    Other names: DIABLO, Diablo IAP-Binding Mitochondrial Protein, SMAC, Second Mitochondria-Derived Activator Of Caspase, DFNA64, Direct IAP-Binding Protein With Low PI, Diablo Homolog, Mitochondrial, DIABLO-S, FLJ25049, FLJ10537, Diablo, IAP-Binding Mitochondrial Protein, Diablo-Like Protein, Smac
    Associations

    News

    Trials
    9ms
    SMAC/DIABLO: A Guardian Angel in Boosting Anticancer Drug-Induced Apoptosis. (PubMed, Curr Mol Med)
    Recently, we have reported that the overexpression of SMAC in cancers is essential for cell and tumor growth due to non-apoptotic regulation of phospholipid synthesis. The current review is focused on apoptotic and non-apoptotic functions of SMAC and its role in drug resistance.
    Journal
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    DIABLO (Diablo IAP-Binding Mitochondrial Protein)
    1year
    SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by modulating PANoptosis. (PubMed, Biomark Res)
    Our findings demonstrate that the combination of VSV-S and PD1 blockade offers a synergistic therapeutic strategy for HNSCC, supporting the advancement of VSV-based virotherapy as a promising strategy to improve outcomes for HNSCC patients.
    Journal
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • DIABLO (Diablo IAP-Binding Mitochondrial Protein)
    1year
    Smac/DIABLO protein acts as an independent prognostic factor in oral squamous cell carcinoma. (PubMed, Sci Rep)
    Low proapoptotic protein Smac/DIABLO expression significantly influences prognostic predictions and strongly correlates with poor OSCC outcomes. Future studies involving Smac-mimetic drugs in OSCC are needed to evaluate their pro-apoptotic potential in cancer cells.
    Journal
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    DIABLO (Diablo IAP-Binding Mitochondrial Protein)
    almost3years
    The Role of Apoptotic Genes and Protein-Protein Interactions in Triple-negative Breast Cancer. (PubMed, Cancer Genomics Proteomics)
    Our findings demonstrate that CASP2, CASP3, DAPK1, TNF, TRAF2, and TRAF3 were substantially associated with the overall survival rate (OS) difference of TNBC patients out of a total of 27 specific genes used in this study, which may play crucial roles in the development of TNBC and offer promising therapeutic interventions.
    Journal
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    AR (Androgen receptor) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • MCL1 (Myeloid cell leukemia 1) • RARA (Retinoic Acid Receptor Alpha) • FADD (Fas associated via death domain) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • BNIP3 (BCL2 Interacting Protein 3) • DAPK1 (Death Associated Protein Kinase 1) • TNFRSF10B (TNF Receptor Superfamily Member 10b) • CASP4 (Caspase 4) • DIABLO (Diablo IAP-Binding Mitochondrial Protein)
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    MCL1 expression
    almost3years
    In Vitro Pro-Apoptotic and Anti-Migratory Effects of Marantodes pumilum (syn. Labisia pumila) Extracts on Human Prostate Cancer Cell Lines: Bioguided Isolation of 5-Henicosene-1-yl-resorcinol. (PubMed, Plants (Basel))
    These effects were accompanied by the downregulation of both VEGF-A and CXCL-12 gene expressions (p < 0.001). A monounsaturated 5-alkyl resorcinol was isolated as the active compound in the MPc extract and identified as 5-henicosene-1-yl-resorcinol.
    Preclinical • Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • BAX (BCL2-associated X protein) • CASP7 (Caspase 7) • ANXA5 (Annexin A5) • DIABLO (Diablo IAP-Binding Mitochondrial Protein)
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    CXCL12 expression
    over3years
    Non-apoptotic activity of the mitochondrial protein SMAC/Diablo in lung cancer: Novel target to disrupt survival, inflammation, and immunosuppression. (PubMed, Front Oncol)
    These results suggest that SMAC is involved in multiple processes that are essential for tumor growth and progression. Thus, targeting SMAC's non-canonical function is a potential strategy to treat cancer.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • TNFA (Tumor Necrosis Factor-Alpha) • DIABLO (Diablo IAP-Binding Mitochondrial Protein)