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    BIOMARKER:

    DHRS2 expression

    i
    Other names: DHRS2, Dehydrogenase/Reductase 2, Dehydrogenase/Reductase SDR Family Member 2, Mitochondrial, Short Chain Dehydrogenase/Reductase Family 25C Member 1, Dehydrogenase/Reductase (SDR Family) Member 2, Dicarbonyl Reductase HEP27, Protein D, SDR25C1, Short Chain Dehydrogenase/Reductase Family 25C, Member 1, Short-Chain Alcohol Dehydrogenase Family Member, Dehydrogenase/Reductase Member 2, HEP27
    Entrez ID:
    10202
    Associations

    News

    Trials
    over1year
    DHRS2-induced SPHK1 downregulation contributes to the cell growth inhibition by Trichothecin in colorectal carcinoma. (PubMed, Biochim Biophys Acta Mol Cell Res)
    The present study provides a mechanistic connection among metabolic enzymes, metabolites, and the malignant progression of CRC. Moreover, TCN could be developed as a potential pharmacological tool against CRC by the induction of DHRS2 and targeting SPHK1/S1P metabolic pathway.
    Journal
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    DHRS2 (Dehydrogenase/Reductase 2) • SPHK1 (Sphingosine Kinase 1)
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    DHRS2 expression
    almost2years
    A comprehensive characterization of the dehydrogenase-reductase DHRS2 and its involvement in histone deacetylase inhibition. (PubMed, Exp Cell Res)
    With the emphasis on urologic malignancies (testicular germ cell tumors, urothelial-, prostate-, and renal cell carcinoma), this study concluded that elevated DHRS2 levels could be indicative of a successful HDACi treatment and, thereby offering a novel putative predictive biomarker.
    Journal • Epigenetic controller
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    DHRS2 (Dehydrogenase/Reductase 2)
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    DHRS2 expression
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    quisinostat (JNJ 26481585)
    over2years
    STAMBPL1 promotes the progression of lung adenocarcinoma by inhibiting DHRS2 expression. (PubMed, Transl Oncol)
    The expression of STAMBPL1 mRNA is significantly up-regulated in LUAD, promoting the progression of LUAD by down-regulating the expression of DHRS2 and acting as a potential biomarker of LUAD.
    Journal
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    DHRS2 (Dehydrogenase/Reductase 2) • STAMBPL1 (STAM Binding Protein Like 1)
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    DHRS2 expression
    over2years
    Regulatory mechanism of DHRS2-modified human umbilical cord mesenchymal stem cells-derived exosomes in prostate cancer cell proliferation and apoptosis. (PubMed, Tissue Cell)
    Briefly, DHRS2 was repressed in PCa cells. DHRS2-modified hUC-MSCs-derived exos blocked PCa cell proliferation and enhanced apoptosis.
    Journal
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    DHRS2 (Dehydrogenase/Reductase 2)
    |
    DHRS2 expression