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    GENE:

    DHDH (Dihydrodiol Dehydrogenase)

    i
    Other names: DHDH, Dihydrodiol Dehydrogenase, Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase, HUM2DD, D-Xylose-NADP Dehydrogenase, D-Xylose 1-Dehydrogenase, 2DD, Dihydrodiol Dehydrogenase (Dimeric), Dimeric Dihydrodiol Dehydrogenase, 3-Deoxyglucosone Reductase, Hum2DD
    Associations

    News

    Trials
    3years
    A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy. (PubMed, J Exp Clin Cancer Res)
    In conclusion, this study broadened our understanding of the functions of lncRNAs in GBM. We demonstrated that the tumor suppressor MDHDH might act as a clinical biomarker and that the overexpression of MDHDH might be a novel synergistic strategy for enhancing metabolism-based, epigenetic-based, and autophagy regulation-based therapies with clinical benefits for glioblastoma multiforme patients.
    Journal
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    PSMA1 (Proteasome 20S Subunit Alpha 1) • DHDH (Dihydrodiol Dehydrogenase)