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    GENE:

    DGKZ (Diacylglycerol Kinase Zeta)

    i
    Other names: DGKZ, Diacylglycerol Kinase Zeta, DAGK6, HDGKzeta, DGK-ZETA, DAGK5, Diacylglycerol Kinase, Zeta 104kDa, Diglyceride Kinase Zeta, DAG Kinase Zeta, DGK-Zeta
    Associations

    News

    Trials
    5ms
    Integrating genetic regulation and schizophrenia-specific splicing quantitative expression with GWAS prioritizes novel risk genes for schizophrenia. (PubMed, Transl Psychiatry)
    Overall, our findings highlight several susceptibility genes that may contribute to SCZ risk by AS regulation. Further characterization of these genes could advance mechanistic understanding and therapeutic discovery for SCZ.
    Journal
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    DPYD (Dihydropyrimidine Dehydrogenase) • DGKZ (Diacylglycerol Kinase Zeta)
    11ms
    Enhanced Antitumor Immunity by ASP1570, a Novel Diacylglycerol Kinase Zeta Inhibitor, Offers a Potential Novel Immunotherapy for Treating Cancer. (PubMed, Mol Cancer Ther)
    The antitumor efficacy of ASP1570 was cancelled by CD8+ T-cell depletion, indicating that its antitumor effect depends on CD8+ cytotoxic T-cell activation. Collectively, ASP1570 potentially improves antitumor efficacy in both anti-PD-1-therapy-resistant and anti-PD-1-therapy-responsive tumors by overcoming multiple immunosuppressive signals.
    Journal
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    CD8 (cluster of differentiation 8) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • TGFB1 (Transforming Growth Factor Beta 1) • DGKZ (Diacylglycerol Kinase Zeta)
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    ASP1570
    over1year
    Distinctive genomic features of human T-lymphotropic virus type 1-related adult T-cell leukemia-lymphoma in Western populations. (PubMed, Haematologica)
    IRF4 and CARD11 mutations frequently emerged in relapses after interferon therapy. Our findings reveal novel putative ATLL driver genes and clinically relevant differences between Japanese and Western ATLL patients.
    Journal
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    CARD11 (Caspase Recruitment Domain Family Member 11) • ANKRD1 (Ankyrin Repeat Domain 1) • IRF4 (Interferon regulatory factor 4) • FOXO3 (Forkhead box O3) • GATA3 (GATA binding protein 3) • DGKZ (Diacylglycerol Kinase Zeta)
    over1year
    Development of prognostic signatures and risk index related to lipid metabolism in ccRCC. (PubMed, Front Oncol)
    The different LMRS groups were suitable for different anticancer drug treatment regimens. Prognostic signatures and LMRS we developed may be applied to the risk assessment of ccRCC patients, which may have potential guiding significance in the diagnosis and precise treatment of ccRCC patients.
    Journal • IO biomarker
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    ACAT1 (Acetyl-CoA Acetyltransferase 1) • DGKZ (Diacylglycerol Kinase Zeta) • ACADM (Acyl-CoA Dehydrogenase Medium Chain)
    almost2years
    Integration of network pharmacology, lipidomics, and transcriptomics analysis to reveal the mechanisms underlying the amelioration of AKT-induced nonalcoholic fatty liver disease by total flavonoids in vine tea. (PubMed, Food Funct)
    Furthermore, we used immunohistochemistry (IHC) to detect changes in the protein levels of the key proteins PPARγ and SCD1. In summary, TF can improve hepatic steatosis by targeting the PPAR signaling pathway, thereby reducing de novo fatty acid synthesis and modulating the glycerophospholipid metabolism.
    Journal
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    PPARG (Peroxisome Proliferator Activated Receptor Gamma) • DGKZ (Diacylglycerol Kinase Zeta)
    almost2years
    A novel CD8+ T cell-related gene signature as a prognostic biomarker in hepatocellular carcinoma. (PubMed, Medicine (Baltimore))
    Finally, drug sensitivity data indicated that 10 chemotherapeutic drugs held promise as therapeutics for HCC patients with high-risk. In conclusion, multi-databases analysis showed that 5-CD8Gs and their signature could be an indicator to predict candidate drugs for HCC therapy.
    Journal • Gene Signature
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    CD8 (cluster of differentiation 8) • FCER1G (Fc Fragment Of IgE Receptor Ig) • DGKZ (Diacylglycerol Kinase Zeta) • KLRB1 (Killer Cell Lectin Like Receptor B1) • IL2RG (Interleukin 2 Receptor Subunit Gamma)
    over2years
    The Regulation Network of Glycerolipid Metabolism as Coregulators of Immunotherapy-Related Myocarditis. (PubMed, Cardiovasc Ther)
    Finally, the hub-regulated protease of diacylglycerol kinase zeta (Dgkz) was significantly identified and widely played various roles in glycerolipid metabolism, oxidative phosphorylation, and lipid kinase activation. Mitochondrial-regulated glycerolipid metabolism, especially the DGKZ protein, plays a key role in the metabolic reprogramming of immunotherapy-related myocarditis.
    Journal
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    PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • DGKZ (Diacylglycerol Kinase Zeta)
    over3years
    Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. (PubMed, Int J Mol Sci)
    Taken together, these data suggest that BPA plays a role in colon carcinogenesis, and they provide insights into the molecular mechanisms of colon epithelial cell transformation by BPA. Increasing exposure to environmental toxins such as BPA can explain the increasing incidence of colorectal cancer.
    Journal
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    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CHEK2 (Checkpoint kinase 2) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • HMOX1 (Heme Oxygenase 1) • WNK1 (WNK Lysine Deficient Protein Kinase 1) • STAT2 (Signal transducer and activator of transcription 2) • AKT1S1 (AKT1 Substrate 1) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) • DGKZ (Diacylglycerol Kinase Zeta) • MAPK8 (Mitogen-activated protein kinase 8) • VMP1 (Vacuole Membrane Protein 1)
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    5-fluorouracil
    almost4years
    DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2. (PubMed, Cell Death Dis)
    Moreover, the caveolin/lipid raft-dependent endocytosis of TGFβR2 was regulated by the metabolite phosphatidic acid, which might alter TGFβR2 partitioning in lipid rafts and nonlipid rafts by affecting the fluidity of the plasma membrane. These findings suggested that DGKZ is a novel promoter of metastasis and that it could be a potential prognostic indicator in patients with triple-negative breast cancer.
    Journal
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    TGFBR2 (Transforming Growth Factor Beta Receptor 2) • DGKZ (Diacylglycerol Kinase Zeta) • SMAD3 (SMAD Family Member 3)
    almost4years
    Mechanisms of resistance to CLN-081 (TAS6417) in non-small cell lung cancer with EGFR exon 20 insertions (AACR 2022)
    NSCLC with EGFR exon 20 insertions is resistance to conventional epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as osimertinib. Our preclinical study identified several mechanisms of resistance to CLN-081 including acquired mutations and inflammatory responses. These results will provide new insights into development of a novel strategy to overcome or prevent resistance to CLN-081.
    EGFR exon 20
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    EGFR (Epidermal growth factor receptor) • KMT2C (Lysine Methyltransferase 2C) • PAK2 (P21 (RAC1) Activated Kinase 2) • DGKZ (Diacylglycerol Kinase Zeta)
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    EGFR mutation • EGFR exon 20 insertion • EGFR expression • EGFR C797S • EGFR exon 20 mutation • KMT2C mutation
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    Tagrisso (osimertinib) • zipalertinib (CLN-081)