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DRUG:

radgocitabine (DFP-10917)

i
Other names: DFP-10917, DFP10917, NS 917, TAS-109, CNDAC, DFP 10917, NS917, NS-917, TAS109, TAS 109
Associations
Company:
Delta-Fly Pharma, Nippon Shinyaku
Drug class:
DNA-directed DNAP inhibitor, G2 checkpoint inhibitor
Associations
4ms
DFP-10917 in Combination With Venetoclax in Relapsed or Refractory Acute Myeloid Leukemia (clinicaltrials.gov)
P1/2, N=39, Recruiting, Delta-Fly Pharma, Inc. | Not yet recruiting --> Recruiting
Enrollment open
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Venclexta (venetoclax) • radgocitabine (DFP-10917)
8ms
New P1/2 trial • Combination therapy
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Venclexta (venetoclax) • radgocitabine (DFP-10917)
over1year
A polyethylene glycol-conjugate of deoxycytidine analog, DFP-14927, produces potential antitumor effects on pancreatic tumor-xenograft murine models via inducing G2/M arrest. (PubMed, Eur J Pharmacol)
These effects were comparable to that of free DFP-10917 as well as to that of gemcitabine, which is considered a standard in the treatment of pancreatic cancer. Intravenous administration of the newly synthesized DFP-14927 has induced G2/M arrest in human pancreatic tumor-xenograft murine models, which represents an improvement in the pharmacokinetics of DFP-10917. DFP-14927 could be an alternative for patients who cannot accept prolonged or continuous infusions of DFP-10917.
Preclinical • Journal
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gemcitabine • radgocitabine (DFP-10917)