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DRUG:

DF8100

i
Other names: DF8100
Associations
Trials
Company:
Dragonfly Therap, Merck (MSD)
Drug class:
NK cell stimulant
Related drugs:
Associations
Trials
almost2years
GOLM1 is related to the inflammatory/immune nature of uveal melanoma and acts as a promising indicator for prognosis and immunotherapy response. (PubMed, Front Genet)
Moreover, tumor tissue sections from 23 UVM patients were collected and stained for GOLM1 (1:300; cat# DF8100, Affinity Biosciences), PD-L1 (1:250; cat# ab213524, Abcam), PD-1 (1:100; cat# ab52587, Abcam), CTLA-4 (1:300; cat# DF6793, Affinity Biosciences), and IFN-γ (1:300; cat# DF6045, Affinity Biosciences)...Gene pattern and SubMap analyses confirmed the indicator role of GOLM1 in predicting immunotherapy response in UVM. Taken together, GOLM1 is a novel prognostic marker, and it can be employed to predict the overall survival outcomes and treatment responses of anti-PD-1/PD-L1 and anti-CTLA4 therapies for UVM patients.
Journal • PD(L)-1 Biomarker • IO biomarker
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IFNG (Interferon, gamma)
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PD-L1 expression
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DF8100