^
    2d
    Stellate Ganglion Block Versus Oral Medication in Treatment of Palmar Hyperhidrosis (clinicaltrials.gov)
    P=N/A, N=46, Completed, Fayoum University | Recruiting --> Completed
    Trial completion
    |
    dexamethasone • dexamethasone injection
    2d
    DURGA-4: A Phase III, Open-label, Randomised, Multicentre Study to Evaluate AZD0120 in Participants With Relapsed Refractory Multiple Myeloma. (clinicaltrials.gov)
    P3, N=508, Not yet recruiting, AstraZeneca
    New P3 trial
    |
    bortezomib • Darzalex (daratumumab) • carfilzomib • dexamethasone • pomalidomide • AZD0120
    2d
    DoMMino-1: Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov)
    P2, N=100, Recruiting, CellCentric Ltd. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    dexamethasone • pomalidomide • inobrodib (CCS1477)
    3d
    Perioperative Steroid Dosing on the APR in AIS (clinicaltrials.gov)
    P4, N=50, Recruiting, Emory University | Trial completion date: Dec 2025 --> Mar 2026 | Trial primary completion date: Dec 2025 --> Mar 2026
    Trial completion date • Trial primary completion date
    |
    dexamethasone
    4d
    Largely Distinct Post-Translational Modifications Differentiate Skeletal Muscle Wasting Caused by Cancer, Dexamethasone and Aging. (PubMed, J Cachexia Sarcopenia Muscle)
    These analyses identify atrophy-associated PTMs that provide refined biomarkers for fingerprinting the atrophic stimulus. Although most PTMs are stimulus-specific, P27 dihydroxylation of Lrpprc declines during muscle wasting induced by cancer, dexamethasone and aging, suggesting that this is a general atrophy marker. Experimental up-regulation of the atrophy-mimicking variant LrpprcP27A reduces muscle force compared to wild-type Lrpprc in young and old mice, suggesting that atrophy-associated P27 dihydroxylation contributes to disease-associated muscle weakness.
    Journal
    |
    COL6A2 (Collagen Type VI Alpha 2 Chain) • LRPPRC (Leucine Rich Pentatricopeptide Repeat Containing)
    |
    dexamethasone
    5d
    GMMG-HD7: Trial on the Effect of Isatuximab to Lenalidomide/Bortezomib/Dexamethasone (RVd) Induction and Lenalidomide Maintenance in Patients With Newly Diagnosed Myeloma (GMMG HD7) (clinicaltrials.gov)
    P3, N=662, Active, not recruiting, University of Heidelberg Medical Center | Trial completion date: Mar 2027 --> Jun 2028 | Trial primary completion date: May 2025 --> Jun 2028
    Trial completion date • Trial primary completion date
    |
    lenalidomide • bortezomib • doxorubicin hydrochloride • cyclophosphamide • dexamethasone • Sarclisa (isatuximab-irfc) • dexamethasone injection
    6d
    CCTG LY18-A: Phase I Master Protocol of Novel Combination Therapy for Patients With Relapsed or Refractory Aggressive B-Cell Lymphoma (clinicaltrials.gov)
    P1, N=18, Recruiting, Canadian Cancer Trials Group | Trial completion date: Jul 2026 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
    |
    Venclexta (venetoclax) • cisplatin • gemcitabine • dexamethasone • Rituxan Hycela (rituximab/hyaluronidase) • Monjuvi (tafasitamab-cxix) • Columvi (glofitamab-gxbm)
    6d
    Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma (clinicaltrials.gov)
    P2, N=84, Recruiting, Canadian Cancer Trials Group | Trial completion date: Jun 2026 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
    |
    Keytruda (pembrolizumab) • cisplatin • gemcitabine • Adcetris (brentuximab vedotin) • dexamethasone
    6d
    Dexamethasone vs Dexmedetomidine in Sphenopalatine Ganglion Block for Rhinoplasty Pain (clinicaltrials.gov)
    P1, N=90, Enrolling by invitation, Ain Shams University
    New P1 trial
    |
    dexamethasone
    6d
    Mezigdomide combined with bortezomib disrupts the cell cycle and elicits superior antitumor effects in multiple myeloma. (PubMed, Blood Neoplasia)
    Triplet regimens that include an immunomodulatory agent, proteasome inhibitor, and dexamethasone are widely used in newly diagnosed and relapsed/refractory (R/R) multiple myeloma (MM)...Additionally, we have compared these results with similar combinations with the immunomodulatory agent pomalidomide (POM). Our studies indicate that the MEZI/BTZ/DEX triplet is superior to all single agents and POM/BTZ/DEX in terms of potency of antiproliferative and proapoptotic activities, substrate degradation depth and kinetics in the presence of BTZ, and in vivo efficacy. We show that the combination of MEZI with BTZ increases cell death through disruption of multiple phases of the cell cycle and this thereby enhances the direct cytotoxic effects of the combination treatment.
    Journal
    |
    IKZF1 (IKAROS Family Zinc Finger 1) • CRBN (Cereblon)
    |
    bortezomib • dexamethasone • pomalidomide • mezigdomide (CC-92480)
    6d
    Increased immunogenicity of hypermutated SB28 syngeneic glioblastoma is partially mediated by alterations in tumor chemokine expression. (PubMed, Neurooncol Adv)
    Clones were injected subcutaneously or intracranially with or without anti-PD-1/anti-CTLA4 and dexamethasone...Rather, rejection depended on increased secretion of pro-inflammatory chemokines. Msh2 and Mlh1 loss was not equivalent, suggesting that additional studies are needed to elucidate germline and somatic mismatch repair gene-specific immune alterations.
    Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
    |
    TMB (Tumor Mutational Burden) • IFNG (Interferon, gamma) • MLH1 (MutL homolog 1) • MSH2 (MutS Homolog 2) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • RAG1 (Recombination Activating 1)
    |
    TMB-H • MSI-H/dMMR • TMB-L
    |
    dexamethasone
    9d
    Comparing the effects of cyclopofol and propofol on postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery (ChiCTR2600117588)
    P=N/A, N=222, Not yet recruiting, Southern Medical University Southern Hospital; Southern Medical University Southern Hospital
    New trial
    |
    dexamethasone • Sufenta (sufentanil)