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    BIOMARKER:

    DEK-AFF2 fusion

    i
    Other names: DEK, DEK Proto-Oncogene, DEK Oncogene, Protein DEK, MRX2, Protein Ox19, FRAXE, Fragile X Mental Retardation 2, FMR2, OX19, FMR2P, Protein FMR-2, Fragile X Mental Retardation 2 Protein, AFF2, AF4/FMR2 Family Member 2, Fragile X E Mental Retardation Syndrome Protein
    Entrez ID:
    2334; 7913
    Related biomarkers:
    Mutation
    5ms
    Prevalence and interpretation of AFF immunostain of DEK::AFF2 fusion-associated papillary squamous cell carcinoma in a retrospective cohort of recurrent sinonasal papillomas. (PubMed, Virchows Arch)
    Granular, cytoplasmic, or incomplete AFF staining should be considered as negative. In view of the rarity of DEK::AFF2 carcinomas, plasma cells and plasma cell neoplasms are potential for internal and surrogate external controls.
    Retrospective data • Journal
    |
    AFF2 (AF4/FMR2 family member 2) • DEK (DEK Proto-Oncogene)
    |
    DEK-AFF2 fusion
    6ms
    The First Report of Cytology of DEK::AFF2 Fusion-Associated Papillary Squamous Cell Carcinoma on Fine-Needle Aspiration. (PubMed, Head Neck Pathol)
    Our finding suggests that in nodal aspirates of patients with a history of sinonasal-type papillomas, especially those with prior malignant transformation or atypia, there should be consideration for the possibility of DEK::AFF2-related primary. When in doubt, DEK FISH of AFF2 immunohistochemistry should be performed for confirmation.
    Journal • Cytology
    |
    AFF2 (AF4/FMR2 family member 2)
    |
    DEK-AFF2 fusion
    7ms
    Primary DEK::AFF2 fusion positive nonkeratinizing squamous cell carcinoma of the middle ear: report of a case (PubMed, Zhonghua Bing Li Xue Za Zhi)
    No abstract available
    Journal
    |
    AFF2 (AF4/FMR2 family member 2)
    |
    DEK-AFF2 fusion
    1year
    Sinonasal Adenosquamous Carcinoma - Morphology and Genetic Drivers Including Low- and High-Risk Human Papillomavirus mRNA, DEK::AFF2 Fusion, and MAML2 Rearrangement. (PubMed, Head Neck Pathol)
    Sinonasal adenosquamous carcinoma is a somewhat heterogeneous tumor not infrequently arising ex papilloma and having various drivers including high- and low-risk HPV and rarely DEK::AFF2 fusion. The prognosis appears favorable when proper treatment is possible.
    Journal
    |
    AFF2 (AF4/FMR2 family member 2) • MAML2 (Mastermind Like Transcriptional Coactivator 2)
    |
    CDKN2A negative • DEK-AFF2 fusion
    over1year
    DEK::AFF2 Fusion Carcinomas of Head and Neck. (PubMed, Adv Anat Pathol)
    This tumor behaves aggressively involving adjacent vital structures, frequently recurs, and is inclined to develop lymph node and distant metastasis. This review aims to summarize the demographic, clinical, pathologic, immunophenotypic features, and pattern of molecular alterations as well as to discuss the differential diagnosis of DEK::AFF2 fusion carcinoma.
    Journal
    |
    AFF2 (AF4/FMR2 family member 2)
    |
    DEK-AFF2 fusion