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    GENE:

    DDX3X (DEAD-Box Helicase 3 X-Linked)

    i
    Other names: DDX3X, DEAD-Box Helicase 3 X-Linked, HLP2, DBX, DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked, DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, X-Linked, DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 3, DEAD Box Protein 3, X-Chromosomal, ATP-Dependent RNA Helicase DDX3X, Helicase-Like Protein 2, DEAD Box, X Isoform, CAP-Rf, DDX14, DEAD/H Box-3, MRX102, MRXSSB
    Associations

    News

    Trials
    13d
    Revealing the function and mechanism of piRNA-related genes in bladder cancer through single-cell sequencing and methylation analyses and construction of prognostic features based on consensus clustering. (PubMed, Curr Urol)
    This study effectively developed a 3-gene prognostic signature comprising MAPK13, INHBA, and LAMB2 using consensus clustering and multifactorial logistic regression. In addition, the functional roles and intrinsic mechanisms of piRPGs in bladder carcinogenesis were comprehensively explored using single-cell sequencing, methylation sequencing, and functional enrichment analysis.
    Journal
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    CDK2 (Cyclin-dependent kinase 2) • DDX3X (DEAD-Box Helicase 3 X-Linked) • LAMC1 (Laminin Subunit Gamma 1)
    14d
    EBV-Driven NK/T-Cell Lymphoproliferative Disorders: Clinical Diversity and Molecular Insights. (PubMed, Lymphatics)
    These findings suggest all EBV+ NK/T-cell LPDs exist on a biological continuum of viral oncogenesis. The integration of clinical, pathological, and molecular information aims to create a more accurate classification system, enabling better risk evaluation and tailored treatment strategies for patients with these complex disorders.
    Journal
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    KMT2D (Lysine Methyltransferase 2D) • DDX3X (DEAD-Box Helicase 3 X-Linked)
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    TP53 mutation
    2ms
    Epstein-Barr Virus-Associated T/NK-Cell Neoplasms. (PubMed, J Med Virol)
    l-asparaginase-based chemoradiotherapy has improved outcomes in early-stage ENKTL; however, effective treatments for advanced-stage disease and other EBV-associated T/NK-cell neoplasms remain limited. Emerging molecular subclassifications and large-scale prospective cohorts can help clarify disease heterogeneity and accelerate the development of precision therapeutic strategies.
    Review • Journal
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    TP53 (Tumor protein P53) • DDX3X (DEAD-Box Helicase 3 X-Linked)
    2ms
    Integrative analysis of single-cell and bulk RNA sequencing data for discovery of senescent TAMs prognostic characteristics in neuroblastoma. (PubMed, BMC Cancer)
    Senescent TAMs influence NB immunosuppression and progression. EIF5 is a key regulator of TAM senescence and a potential therapeutic target. Our risk model may guide clinical stratification and targeted interventions.
    Journal
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    CD8 (cluster of differentiation 8) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL10 (Interleukin 10) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • BRD2 (Bromodomain Containing 2) • DDX3X (DEAD-Box Helicase 3 X-Linked) • LILRB1 (Leukocyte Immunoglobulin Like Receptor B1) • SLC43A2 (Solute Carrier Family 43 Member 2)
    2ms
    Mutational Spectrum of T-Cell Large Granular Lymphocytic Leukemia: Insights From the AACR Project GENIE Consortium. (PubMed, Cancer Genomics Proteomics)
    This study provides a comprehensive genomic profile of T-LGLL, identifying recurrent somatic mutations and commonly affected pathways. Notably, frequent alterations were observed in the FAS-FASL signaling pathway, underscoring its potential as a target for therapeutic development.
    Retrospective data • Journal
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    EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • DNMT3A (DNA methyltransferase 1) • KMT2D (Lysine Methyltransferase 2D) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • STAT3 (Signal Transducer And Activator Of Transcription 3) • FASLG (Fas ligand) • IKZF3 (IKAROS Family Zinc Finger 3) • TNFAIP3 (TNF Alpha Induced Protein 3) • EPHB1 (EPH Receptor B1) • SETD1B (SET Domain Containing 1B, Histone Lysine Methyltransferase) • STAT2 (Signal transducer and activator of transcription 2) • ALOX12B (Arachidonate 12-Lipoxygenase) • DDX3X (DEAD-Box Helicase 3 X-Linked)
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    TP53 mutation • STAT3 mutation
    2ms
    Mechanism of the DDX3X/NLRP3/GSDMD Signaling Axis in Pyroptosis and Inflammatory Response in Osteoarthritis Chondrocytes. (PubMed, J Biochem Mol Toxicol)
    NLRP3 or GSDMD overexpression partly counteracted DDX3X knockdown-improved OA chondrocyte pyroptosis and inflammation. Inhibiting the DDX3X/NLRP3/GSDMD axis alleviated chondrocyte pyroptosis and inflammatory response in OA in vitro, thus ameliorating chondrocyte injury.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • ACAN (Aggrecan) • DDX3X (DEAD-Box Helicase 3 X-Linked) • GSDMD (Gasdermin D)
    2ms
    Adult Acute Myeloid Leukaemia With DDX3X::MLLT10: A Rare Entity With Significant Unmet Clinical Needs. (PubMed, EJHaem)
    Collectively, these cases highlight the genomic heterogeneity of this rare entity, as well as significant unmet clinical needs due to the poor prognosis and chemoresistance observed. These findings may inform future iterations of AML classification and prognostication in adults.
    Journal
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    DDX3X (DEAD-Box Helicase 3 X-Linked) • MLLT10 (MLLT10 Histone Lysine Methyltransferase DOT1L Cofactor)
    3ms
    A rare case of large B-cell lymphoma with IRF4 rearrangement and concomitant 11q aberrations: a diagnostic pitfall in the molecular era. (PubMed, Virchows Arch)
    The patient achieved complete remission with R-CHOP therapy, aligning with LBCL-IRF4-R's favorable prognosis. This case underscores the need for integrated morphology, immunophenotyping, and NGS to resolve complex diagnostic challenges. It presents a key diagnostic pitfall where secondary 11q aberrations in LBCL-IRF4-R can mimic HGBL-11q, revealing limitations of current genetic algorithms and advocating for expanded molecular diagnostic criteria.
    Journal • IO biomarker
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • CD20 (Membrane Spanning 4-Domains A1) • PBRM1 (Polybromo 1) • BCL6 (B-cell CLL/lymphoma 6) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • GNA13 (G Protein Subunit Alpha 13) • IRF4 (Interferon regulatory factor 4) • MME (Membrane Metalloendopeptidase) • DDX3X (DEAD-Box Helicase 3 X-Linked)
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    Rituxan (rituximab)
    3ms
    DDX3X promotes ILF3 stability to accelerate neuroblastoma progression via M2 macrophage polarization. (PubMed, Brain Res)
    Actinomycin D treatment combined with RT-qPCR was used to assess ILF3 mRNA stability...In vivo, DDX3X inhibitor, RK-33, markedly inhibited NB tumor growth and metastasis and enhanced M1 macrophage polarization, which was partially reversed by ILF3 overexpression. DDX3X promotes NB progression by stabilizing ILF3 mRNA, thereby facilitating M2 macrophage polarization.
    Journal
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    DDX3X (DEAD-Box Helicase 3 X-Linked) • IL3 (Interleukin 3)
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    dactinomycin
    3ms
    OTUD4-ZMYND8-DDX3X Axis Drives Immunosuppressive Microenvironment in Spinal Metastases of Triple-Negative Breast Cancer. (PubMed, Neoplasia)
    The resulting OTUD4-ZMYND8-DDX3X signaling axis drives canonical WNT/β-catenin signaling, upregulates CSF1 expression and promotes M2 polarization of macrophages, collectively fostering invasive behavior and establishing an immunosuppressive niche conducive to spinal metastasis. Collectively, these findings establish the OTUD4-ZMYND8-DDX3X axis as a pivotal regulator of spinal metastasis in TNBC and highlight its potential as a therapeutic target for inhibiting metastatic progression.
    Journal
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    CSF1 (Colony stimulating factor 1) • ZMYND8 (Zinc Finger MYND-Type Containing 8) • DDX3X (DEAD-Box Helicase 3 X-Linked)
    4ms
    Targeting FAM134B-DDX3X axis inhibiting AKT signaling in hepatocellular carcinoma. (PubMed, Cell Death Dis)
    Lastly, we explored the therapeutic potential of combining the DDX3X inhibitor RK-33 with FAM134B knockdown in HCC treatment. Our findings indicate that this synergistic approach may offer a promising strategy for HCC therapy.
    Journal
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    RAC1 (Rac Family Small GTPase 1) • DDX3X (DEAD-Box Helicase 3 X-Linked)
    4ms
    Clinico-hematopathologic and Genetic Characteristics of Korean Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm: A Retrospective Single-center Cohort Study. (PubMed, Ann Lab Med)
    Network analysis revealed functional associations between these novel alterations and established BPDCN-related genes. We present the first network-based analysis of Korean patients with BPDCN, along with conventional genetic assessments, highlighting the potential genetic drivers of BPDCN and facilitating the development of targeted therapies for the disease.
    Retrospective data • Journal
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    ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • DDX3X (DEAD-Box Helicase 3 X-Linked)