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DRUG:

DC-AdGMCAIX

i
Other names: DC-AdGMCAIX, DC AdGM CAIX, Ad-GMCAIX transduced dendritic cells, AdGMCA9, DCs expressing CMCA9 gene therapy, AdGMCAIX-transduced dendritic cells
Associations
Company:
Gilead
Drug class:
Immunostimulant
Related drugs:
Associations
over3years
Autologous Dendritic Cells in Treating Patients With Metastatic Kidney Cancer (clinicaltrials.gov)
P1, N=12, Completed, Jonsson Comprehensive Cancer Center | Active, not recruiting --> Completed | Trial completion date: Jan 2022 --> May 2021
Clinical • Trial completion • Trial completion date
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CA9 (Carbonic anhydrase 9)
|
DC-AdGMCAIX
4years
A Phase I, Open-label, Dose-escalation, and Cohort Expansion Study to Evaluate the Safety and Immune Response to Autologous Dendritic Cells Transduced With AdGMCA9 (DC-AdGMCAIX) in Patients With Metastatic Renal Cell Carcinoma. (PubMed, J Immunother)
These early data show that autologous immature DC-AdGMCAIX can be safely given to metastatic RCC patients without any serious adverse events with CAIX-specific immune response elicited by the treatment. These preliminary data support further study of Ad-GMCAIX, particularly with combination therapies that may enhance clinical activity.
Clinical • Journal
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CA9 (Carbonic anhydrase 9)
|
CA9 expression
|
DC-AdGMCAIX
over4years
Autologous Dendritic Cells in Treating Patients With Metastatic Kidney Cancer (clinicaltrials.gov)
P1, N=12, Active, not recruiting, Jonsson Comprehensive Cancer Center | Trial completion date: Jan 2020 --> Jan 2022 | Trial primary completion date: Dec 2019 --> Dec 2021
Clinical • Trial completion date • Trial primary completion date
|
CA9 (Carbonic anhydrase 9)
|
DC-AdGMCAIX