It is suggested that, in addition to converting treated metastases into an autologous TA vaccine, this treatment should be considered as a neoadjuvant therapy, administering α-gal micelles into primary tumors immediately following their detection. Such an immunotherapy will convert tumors into a personalized anti-TA vaccine for the period prior to their resection.
19 days ago
Review • Journal
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CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
All cases were successfully managed with hydroxyurea...In conclusion, APL patients undergoing ATRA-ATO therapy with lower fibrinogen levels and platelet counts at diagnosis and with a massive bone marrow blast infiltrate should be carefully monitored for the development of leucocytosis during induction. DS and other treatment-related complications seem to occur almost exclusively in patients developing leucocytosis, who should necessarily receive DS prophylaxis and more intensive monitoring and supportive therapy to prevent treatment complications.
P1, N=62, Recruiting, Dana-Farber Cancer Institute | Trial completion date: Dec 2025 --> Jun 2026 | Trial primary completion date: Dec 2024 --> Jun 2025
3 months ago
Trial completion date • Trial primary completion date • Immunomodulating
Our data demonstrates the potential of activating TNFRSF25 by Abs and multimeric TL1A proteins for cancer immunotherapy and provides insights into their development astherapeutics.
3 months ago
Journal • IO biomarker
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CD8 (cluster of differentiation 8) • CD40 (CD40 Molecule)
Furthermore, these differences were comparably recapitulated in the ability of the tested DCs to induce IFNγ- and IFNγ/TNFα-producing T cells. These findings show a novel mechanism of MC-mediated regulation of adaptive immune responses.
P2, N=110, Terminated, Imcyse SA | Trial completion date: Jan 2025 --> May 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Jan 2025 --> Jan 2024; No efficacy at primary analysis after 1 year. Long term follow-up stopped
5 months ago
Trial completion date • Trial termination • Trial primary completion date
This is the first study reporting that oHSV-induced secreted IGF2 exerts a critical role in resistance to oHSV therapy, which can be overcome by oHSV-D11mt as a promising therapeutic advance for enhanced viro-immunotherapy.
P2, N=170, Active, not recruiting, Queen Mary University of London | Not yet recruiting --> Active, not recruiting | Phase classification: P2b --> P2 | Trial completion date: May 2024 --> May 2025 | Trial primary completion date: Feb 2024 --> Nov 2024
5 months ago
Enrollment closed • Phase classification • Trial completion date • Trial primary completion date • Stroma
In patients with incurable HPV16+ solid tumors treated with SQZ-PBMC-HPV, an increase in CD8+ T cell density within the tumor parenchyma was associated with superior disease control rate and overall survival. The product composition for patients with increased CD8+ T cell density was enriched for T cells.
7 months ago
P1 data • Journal
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CD8 (cluster of differentiation 8) • HLA-A (Major Histocompatibility Complex, Class I, A) • GZMB (Granzyme B)
P1/2, N=6, Terminated, Eureka Therapeutics Inc. | N=12 --> 6 | Trial completion date: Jun 2026 --> Jun 2023 | Recruiting --> Terminated | Trial primary completion date: Apr 2024 --> Jun 2023; Directing efforts to the pediatric study (ARYA-2) for this product
7 months ago
Enrollment change • Trial completion date • Trial termination • Trial primary completion date • Metastases
P2/3 | N=700 | NCT05141721 | Sponsor: Gritstone bio, Inc. | "Gritstone bio...announced positive preliminary data from the ongoing, signal seeking Phase 2 portion of the Phase 2/3 study evaluating GRANITE...in front-line metastatic microsatellite stable colorectal cancer (MSS-CRC)....Early progression-free survival (PFS) trends favor GRANITE recipients with hazard ratios of 0.82 in the overall population ([95% CI, 0.34-1.67]; 62% censored) and 0.52 (48% relative risk reduction of progression or death with GRANITE vs. control) in a high-risk group, where clinical data are more mature ([95% CI, 0.15-1.38]; 44% censored); >90% of high-risk patients have liver metastases....GRANITE was generally well-tolerated with manageable adverse events; no patients have discontinued GRANITE due to adverse events....Mature PFS data expected in the third quarter of 2024; overall survival data expected in 1H 2025."
In vitro experiments showed that melanoma EV stimulates dendritic cells (DCs) maturation, and mature dendritic cells induce T lymphocyte activation. Thus, tumor cell-derived EVs can generate anti-tumor immunity in a prophylactic setting and may be potential candidates for cell-free tumor vaccines.
8 months ago
Journal
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma)