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    DRUG CLASS:

    CYP51A1 inhibitor

    Related drugs:
    6d
    The LISA (Lactoferrin InStead of Antibiotics/Antifungals) Feasibility Study (clinicaltrials.gov)
    P=N/A, N=114, Not yet recruiting, Guy's and St Thomas' NHS Foundation Trust | Trial completion date: Jun 2024 --> Dec 2027 | Trial primary completion date: Dec 2023 --> Dec 2027
    Trial completion date • Trial primary completion date
    7d
    Mechanism-guided untargeted-to-targeted lipidomics identifies phosphatidylcholine 38:4 in rat bile as an Abcb4/Mdr2 inhibition marker. (PubMed, Drug Metab Dispos)
    Multistage collision-induced dissociation/mass spectrometry3 fragmentation further confirmed the identity as arachidonyl phosphatidylcholine 18:0/20:4. Its rapid and specific decline in the presence of the Mdr2 inhibitor itraconazole offers a potential new tool for early detection of human multidrug resistance protein 3-related liver injury risk during drug development.
    Preclinical • Journal
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    ABCB4 (ATP Binding Cassette Subfamily B Member 4)
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    itraconazole
    10d
    Pulmonary Cryptococcosis Mimicking Lung Metastasis in a Patient with Pancreatic Cancer: A Case Report and Review of the Literature. (PubMed, Intern Med)
    Postoperatively, fluconazole was administered without recurrence and systemic chemotherapy was resumed. Early histopathological confirmation is crucial to make an accurate diagnosis and select the appropriate management.
    Journal • BRCA Biomarker
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    BRCA2 (Breast cancer 2, early onset) • CA 19-9 (Cancer antigen 19-9)
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    BRCA2 mutation
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    5-fluorouracil • leucovorin calcium
    16d
    Mycological Efficacy and Safety of Ketoconazole 2% Shampoo With a Seven-Day Versus Three-Day Treatment Duration in Pityriasis Versicolor (clinicaltrials.gov)
    P4, N=76, Not yet recruiting, Fakultas Kedokteran Universitas Indonesia
    New P4 trial
    18d
    Pregnane X receptor mitigates aristolochic acid-induced acute kidney injury via p53 ubiquitination. (PubMed, Ren Fail)
    The specific agonist of PXR pregnenolone carbonitrile (PCN) relieved AA-induced AKI in mice, while the PXR inhibitor ketoconazole exacerbated the damage caused by AA in mice. Mechanistically, PXR bound to p53 in BUMPT cells and led to the ubiquitination and degradation of p53, thereby downregulating its expression. Taken as a whole, our data demonstrate that PXR may protect against AA-induced AKI by suppressing p53 expression.
    Journal
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    TP53 (Tumor protein P53)
    1m
    Oral Administration of Itraconazole Induces M1 Polarization of Tumor-associated Macrophages in Gynecological Cancer. (PubMed, In Vivo)
    ITZ treatment was associated with increased infiltration of M1-like TAMs in cancer tissues, suggesting an immunomodulatory effect. These findings support further investigation of ITZ as a potential adjunct in cancer therapy.
    Journal
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    CD163 (CD163 Molecule) • CD86 (CD86 Molecule)
    |
    itraconazole
    1m
    A rare case of ectopic cushing's syndrome caused by renal neuroendocrine tumor. (PubMed, J Diabetes Metab Disord)
    The patient's condition was managed with ketoconazole, potassium supplementation, insulin, and antihypertensive medications while awaiting localization of the ACTH source...Postoperatively, the patient received hydrocortisone to prevent adrenal insufficiency, which was gradually tapered off...This case represents a unique instance of an ACTH-negative renal neuroendocrine tumor potentially secreting CRH that caused ECS. This case highlights the importance of considering renal tumors in the differential diagnosis of ECS.
    Journal
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    PAX8 (Paired box 8) • SYP (Synaptophysin)
    1m
    Treatment of congenital nephrogenic diabetes insipidus with fluconazole an antifungal medication. (2024-517438-16-00`2020-002204-38)
    P1/2, N=10, Completed, Odense University Hospital | Recruiting --> Completed
    Trial completion
    2ms
    Itraconazole Therapy In Bronchiectasis With Airway Mold (clinicaltrials.gov)
    P4, N=30, Recruiting, Mayo Clinic | Not yet recruiting --> Recruiting | Initiation date: Dec 2025 --> Mar 2026
    Enrollment open • Trial initiation date
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    itraconazole
    2ms
    The Role of EDHFs on Blood Pressure Following a Bout of Prolonged Sitting (clinicaltrials.gov)
    P=N/A, N=40, Recruiting, Université de Sherbrooke
    New trial
    2ms
    A Study in Healthy People to Test How Itraconazole Influences the Amount of BI 3031185 in the Blood (clinicaltrials.gov)
    P1, N=14, Completed, Boehringer Ingelheim | Active, not recruiting --> Completed
    Trial completion
    |
    itraconazole
    2ms
    A Phase 2 Study to Assess the Effectiveness of Topical Terbinafine in Participants With Mild to Moderate Onychomycosis of the Toenails (clinicaltrials.gov)
    P2, N=200, Not yet recruiting, Onyx Axiom
    New P2 trial