CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9)

Importantly, using the GraphBAN deep learning framework and ADMET-AI screening, we prioritized candidate compounds targeting CYP2C9 and G6PD, followed by molecular docking that validated strong binding affinities, suggesting their potential as novel therapeutics. Together, our study demonstrates that KinicI is a powerful AI-enabled platform for prognostic modeling, molecular stratification, and multitarget drug discovery, providing a foundation for precision oncology and resistance-aware treatment strategies in HCC patients.

While they may down-regulate a gene involved with changes in heart rhythm and neurotoxicity (HCN1). In conclusion, our findings reinforced that the triazole fungicides TF and TN, while effective in agriculture, may pose risks to genomic stability in humans, highlighting the importance of biomonitoring studies in exposed populations.

Bioinformatics-identified genes are potential markers for early lung adenocarcinoma detection and management. RT-PCR validation shows AI's effectiveness in identifying biomarkers, enabling prompt treatment to halt disease progression.

P=N/A, N=2000, Recruiting, Tomsk National Research Medical Center of the Russian Academy of Sciences | Trial completion date: Dec 2026 --> Dec 2028 | Trial primary completion date: Sep 2026 --> Sep 2028

This study highlights the potential of untargeted global proteomics in detecting differences in protein expression among various hepatic cell lines and provides a comprehensive database to inform the choice of the cell line in future studies.

CYP3A4 is a major contributor in the metabolism of 6 drugs, followed by CYP3A (3), CYP1A2 (2), CYP3A4/5 (2), and one each by CYP2C9, UGT1A9, CYP2C8, aldehyde oxidase, and other non-CYP enzymes. The present medicinal chemistry perspective is thus expected to be a valuable read for the medicinal and allied sciences community.

Consistently, down-regulation of CYP1A2 and CYP2C9 and up-regulation of HSP90AB1 were shown by immunofluorescence/Western blotting/RT-qPCR, impairing signaling networks and immune homeostasis and ultimately leading to the establishment of hepatotoxicity and carcinogenic microenvironments. Collectively, the TCDD "target binding-pathway dysregulation-immune imbalance-pathological damage" cascade has been systematically delineated, providing novel targets and a theoretical framework for therapeutic intervention against pollutant-associated liver diseases.

This integrated approach highlighted critical molecular targets and pathways modulated by SM, providing a basis for future experimental studies. SM shows potential as a complementary agent in prostate cancer therapy.

P=N/A, N=120, Recruiting, University of Basel | Not yet recruiting --> Recruiting | Initiation date: Sep 2025 --> Dec 2025

In vitro validation confirmed that ICT suppresses HepG2 and Huh7 cells proliferation and migration in a dose-dependent manner, while molecular analyses demonstrated that ICT treatment significantly downregulates CA9, UCK2, and FABP5 expression and simultaneously upregulates CYP2C9, thereby supporting its role in modulating critical oncogenic pathways. Modulation of ICT-targeted genes was found to effectively suppress HCC progression, underscoring their potential value as prognostic biomarkers and ideal therapeutic targets for the treatment of HCC.

AA genotype at G681A in low BMI patients showed the poorest chemotherapy response and lowest PFS (HR>1). CYP2C19 variants (AA) may serve as predictive markers for non-responsiveness towards AC-T chemotherapy in low BMI BC patients, highlighting the need for genetic counselling and nutritional support to improve treatment outcomes.

These results demonstrate the superiority of long-read sequencing in phasing and resolving complex genomic regions enabling more precise pharmacogenomic profiling. As sequencing costs decline with rapid technological advances, long-read sequencing may become the method of choice in clinical pharmacogenomics, enhancing therapeutic safety and efficacy.