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    BIOMARKER:

    CYP2C8 rs1341164

    i
    Other names: CYP2C8, Cytochrome P450 Family 2 Subfamily C Member 8, CPC8, Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 8, Cytochrome P450, Family 2, Subfamily C, Polypeptide 8, S-Mephenytoin 4-Hydroxylase, Cytochrome P450 Form 1, Cytochrome P450 MP-12, Cytochrome P450 MP-20, Cytochrome P450 IIC2, Cytochrome P450 2C8, CYPIIC8, Flavoprotein-Linked Monooxygenase, Microsomal Monooxygenase, Xenobiotic Monooxygenase, MP-12/MP-20, P450 Form 1, CYP2C8DM
    Entrez ID:
    1558
    Related biomarkers:
    Mutation
    over2years
    Single-nucleotide polymorphism associations with efficacy and toxicity in metastatic castration-resistant prostate cancer treated with cabazitaxel. (PubMed, Pharmacogenomics)
    Genetic variants in mCRPC patients could explain different outcomes with cabazitaxel. Nonetheless, the small sample size and the high number of SNPs analyzed mean that the results are only hypothesis-generating and require further validation.
    Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4) • CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) • TUBB1 (Tubulin Beta 1 Class VI)
    |
    CYP2C8 rs1058932 • CYP2C8 rs1341164 • TUBB1 rs151352
    |
    cabazitaxel